¹³C-methacetinový dechový test u pacientů s jaterní cirhózou a dekompenzovaným srdečním selháním

Czech version

Authors: Jana Vránová ¹; Jozef Rosina ¹; Miluše Hendrichová ²; Antonín Vrána ³; Karolína Krátká ²; Jiří Horák ²
Authors‘ workplace: Ústav lékařské biofyziky a lékařské informatiky, 3. lékařská fakulta, Univerzita Karlova ¹; I. interní klinika, 3. lékařská fakulta, Univerzita Karlova, Praha, Česká republika ²; Ústav radiační onkologie, Nemocnice na Bulovce, Praha, Česká republika ³
Published in: Lékař a technika - Clinician and Technology No. 1, 2013, 43, 24-34
Category: Original research

Overview

An overview of new diagnostic device (Wagner Analysen Technik, Germany) is provided. This device uses the ¹³C stable isotope together with non-dispersive infrared selective spectroscopy for non – invasive quantification of hepatic function parameters, including kinetics (type of liver damage) and capacity (percentage of recovery yield of the liver). The short physical principle of infrared spectroscopy and acousto-optical detector of IRIS was presented. In the final section we verified the diagnostic quality of this new diagnostic device (using ANOVA and ROC analysis) on cohort of 103 patients divided into 3 groups according to diagnosis and the various level of liver damage.

Keywords:
¹³C-methacetin, dose, cumulative dose, infrared spectroscopy, transmitance, absorbance, cirrhosis

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