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Liddle’s Syndrome (LS) - an Unusual Cause of Arterial Hypertension


Authors: J. Štarha;  Z. Doležel;  D. Dostálková
Authors‘ workplace: II. dětská klinika LF MU, FN Brno - Dětská nemocnice
Published in: Čes-slov Pediat 2000; (4): 244-247.
Category:

Overview

A 8-year-old-white boy was examined for fatigue, headache and hypertension. Abnormal laboratory parame-ters were hypokalaemia, hypernatraemia, hypocalcaemia, decreased plasma renin activity and low concentrationof blood aldosterone. Liddle’s syndrome was diagnosed. This very rare disease is caused by mutations in the betaor gamma sub-unit of the sodium channel - amiloride sensitive in the distal tubulus. For the therapy decreasedintake of sodium, increased intake of potassium and antihypertensive drugs (amiloride or triamterene) isrecommended.

Key words:
Liddle’s syndrome, hypertension, childhood

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Labels
Neonatology Paediatrics General practitioner for children and adolescents

Article was published in

Czech-Slovak Pediatrics


2000 Issue 4

Most read in this issue
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