Magnetic resonance imaging showing parietal atrophy of the brain in late-onset Alzheimer’s disease

Czech version

Authors: D. Šilhán ^1,2; I. Ibrahim ³; J. Tintěra ³; A. Bartoš ^1,2
Authors‘ workplace: Neurologická klinika 3. LF UK a FN Královské Vinohrady, Praha ¹; Národní ústav duševního zdraví, Klecany ²; Institut klinické a experimentální medicíny, Praha ³
Published in: Cesk Slov Neurol N 2019; 82(1): 91-95
Category: Original Paper
doi: https://doi.org/10.14735/amcsnn201991

Overview

Aim:

Our intention was to assess whether a scoring of parietal atrophy on MRI of the brain using a simple visual assessment named PAS (Parietal Atrophy Score) could be used in the diagnosis of late-onset Alzheimer‘s disease.

Patients and methods:

The structure of the parietal lobes was evaluated by our visual scale named PAS, which is based on semiquantitative scoring of atrophy of three structures in the parietal region: sulcus cingularis posterior, precuneus and parietal gyri. Parietal atrophy was assessed in 24 patients with late-onset Alzheimer‘s disease in the stage of mild dementia (Mini-Mental State Examination; MMSE 21 ± 3 points) and 26 age-matched individuals with normal scores on the MMSE (29 ± 1 point).

Results:

We did not find any statistically significant difference in the size of any structure of the right and left parietal lobe according to the PAS visual scale between control individuals and patients with Alzheimer‘s disease (p > 0.05 in all cases).

Conclusion:

During late-onset Alzheimer‘s disease there is no significant reduction of parietal cortex until the stage of mild dementia compared to normal aging. Parietal atrophy evaluated according to the PAS visual scale is not an appropriate marker to be used in the diagnosis of late-onset Alzheimer‘s disease in mild stages.

Key words:

Parietal Atrophy Score – parietal atrophy – magnetic resonance imaging – Alzheimer‘s disease – dementia – aging – sulcus cingularis posterior – precuneus – parietal gyri

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

磁共振成像显示晚发性阿尔茨海默氏症患者大脑顶叶萎缩

目的:

我们的目的是评估大脑MRI上的顶叶萎缩评分是否可以用于晚发性阿尔茨海默病的诊断。

患者和方法:

顶叶的结构是通过我们命名为PAS的视觉量表来评估的，它是基于对顶叶区域萎缩的三个结构的半定量评分:后扣带沟、楔前叶和顶叶回。对24例晚发阿尔茨海默氏症轻度痴呆(微精神状态检查;MMSE 21±3分)，年龄匹配者26例，MMSE得分正常(29±1分)。

结果:

对照个体与阿尔茨海默病患者的PAS视觉量表比较，未发现左右顶叶结构大小差异有统计学意义(p > 0.05)。

结论:

在晚发性阿尔茨海默病中，直到轻度痴呆阶段，顶叶皮层与正常年龄相比没有明显的减少。根据PAS视觉量表评估的顶叶萎缩并不适合用于轻度迟发性阿尔茨海默病的诊断。

关键词:

顶叶萎缩评分-顶叶萎缩-磁共振成像-阿尔茨海默氏症-痴呆-衰老-颈沟后-楔前叶-顶叶回

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