Uchycení akutní a chronické myeloidní leukemie v NOD scid gamma myši

English version

Autoři: M. Čulen ¹; D. Dvořáková ²; L. Semerád ^1,2; Z. Šustková ^1,2; J. Bouchnerová ^1,2; M. Palacková ^1,2; J. Mayer ^1,2,3; Z. Ráčil ^1,2,3
Působiště autorů: Department of Internal Medicine, Hematology and Oncology, Faculty of Medicine, Masaryk University, Brno ¹; Department of Internal Medicine, Hematology and Oncology, Faculty Hospital Brno, Brno ²; Masaryk University, Central European Institute of Technology, Brno ³
Vyšlo v časopise: Transfuze Hematol. dnes,21, 2015, No. 1, p. 6-12.
Kategorie: Souhrnné práce, původní práce, kazuistiky

Souhrn

Imunodeficitní myši představují zavedený zvířecí model pro xeno-transplantační studie lidských leukemií, který se může použít jako samostatná in vivo metoda pro studium geneze a progrese leukemie, anebo může být po-užit pro potvrzení schopnosti transplantovaných buněk rozvinout leukemii. Tento myší model byl v průběhu času předmětem mnoha modifikací, a tak je v současné době přihojení transplantovaných buněk u akutní a chronické myeloidní leukemie zpravidla dosažitelné, i když ne u všech leukemických vzorků. Tato přehledová práce pojednává o xeno-trasplantačních experimentech u akutní a chronické myeloidní leukemie, ve kterých byl použit myší kmen NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ představující v současnosti standardní animální model. Cílem práce je poskytnou základní náhled do problematiky myších modelů myeloidních leukemií člověka a představit hlavní kritické body při provádění těchto experimentů.

Klíčová slova:
xenograft, NGS myš, AML, CML

Zdroje

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