Dysplastic changes in megakaryopoiesis according to WHO classification 2008
Authors:
A. Buliková; J. Kissová; M. Antošová; L. Antošová; I. Trnavská
Authors‘ workplace:
Oddělení klinické hematologie FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Miroslav Penka, CSc.
Published in:
Vnitř Lék 2010; 56(Supplementum 1): 31-38
Category:
16th Parizek's Days, Ostrava-Poruba, March 25th –26th 2010
Overview
Megakaryocytic dysplasia is frequent finding not only in patients with diagnose of myelodysplastic syndromes but also in wide spectrum of the other clinic situations. In this paper authors summarized the possibilities and also limitations of peripheral blood and bone marrow smears evaluation in the process of diagnose of myelodysplastic syndrome. Usual megakaryopoiesis with respect of morphology point of view is also mentioned during introduce of the paper.
Key words:
megakaryopoiesis – dysplastic changes – myelodysplastic syndrome
Sources
1. Chang Y, Bluteau D, Debili N et al. From hematopoietic stem cells to platelets. J Throm Haemost 2007; 5 (Suppl 1): 318– 327.
2. Fosberg EC, Serwold T, Kogan S et al. New evidence supporting megakarocyte- erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors. Cell 2006; 126: 415– 426.
3. Bain BJ, Clark DM, Wilkins BS. Bone marrow pathology. 4th ed. Wiley- Blackwell 2010: 20– 26.
4. Bessis M. Blood smears reinterpreted (transl. Brechner G). Heidelberg Springer- Verlag Berlin 1977: 129– 144.
5. Roy L, Coullin P, Virat N et al. Asymmetrical segregation of chromosomes with a normal metaphase/ anaphase checkpoint in polyploid megakaryocytes. Blood 2001; 97: 2238– 2247.
6. Mattia G, Vulcano F, Milazzo L et al. Different ploidity levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet release. Blood 2002; 99: 888– 897.
7. Italiano JE, Patel- Hett S, Hartwig JH. Mechanics of proplatelet elaboration. J Thromb Haemost 2007; 5 (Suppl 1): 18– 23.
8. Pecka M, Malý J, Fátorová I et al. Nové pohledy na vývoj megakaryopoézy a trombopoézy. Trans Hemat dnes 2008; 4 (Suppl 1): 21– 22.
9. Bolton- Maggs PHB, Chalmers EA, Collins PW et al. A review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO. Br J Haematol 2006; 135: 603– 633.
10. Brunning RD, Orazi A, Germing U et al. Myelodysplastic syndromes/ neoplasms, overwiew. In: Swerdlow SH, Campo E, Harris NL et al (eds). WHO classification of tumours of haematopoietic and lymphoid tissues. Geneva: WHO Press 2008: 88– 93.
11. Bennett JM, Catovsky D, Daniel MT et al. Proposal for the classification of the acute leukaemias (FAB cooperative group). Br J Haematol 1976; 33: 451– 458.
12. Brunning RD, Bennett JM, Flandrin G et al. Myelodysplastic syndromes: Introduction. In: Jaffe ES, Harris NL, Stein H et al (eds). World Health Organization classification of tumours: Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: ICAC Press 2001: 63– 67.
13. van de Loosdrecht AA, Westers TM, Westra AH et al. Identification of district progrostic subgroups in low- and intermediate- 1- risk myelodysplastic syndromes by flow cytometry. Blood 2008; 111: 1067– 1077.
14. Mufti GJ, Bennett JM, Goasguent J et al. Diagnosis and classification of myelodysplastic syndrome: International working group in morphology of myelodysplastic syndrome (IWGM- MDS) consensus proposals for the definition and enumeration of myeloblasts and ring sideroblasts. Haematologica 2008; 93: 1712– 1717.
15. van de Loosdrecht AA, Alhan C, Béne MCh et al. Standardization of flow cytometry in myelodysplastic syndromes: report from the first European LeukemiaNet working conference on flow cytometry in myelodysplastic syndrome. Haematologica 2009; 94: 1124– 1134.
16. Steensma DP. The changing classification of myelodysplastic syndromes: what’s in a name? Hematology (Am Soc Hematol Educ Program) 2009: 645– 655.
17. Verdiman JW, Brunning RD, Arber DA et al. Introduction and overview of the classification of the myeloid neoplasms. In: Swerdlow SH, Campo E, Harris NL et al. (Eds). WHO classification of tumours of haematopoietic and lymphoid tissues. Geneva: WHO Press 2008: 18– 30.
18. Bain BJ, Clark DM, Wilkins BS. Bone marrow pathology. 4th ed. Wiley- Blackwell 2010: 208– 228.
19. Kačírková P, Campr V. Hematoonkologický atlas krve a kostní dřeně. Praha: Grada Publishing 2007: 55– 88.
20. Hasserrjian RP, Le Beau MM, List AF et al. Myelodysplastic syndrome with isolated del (5q). In: Swerdlow SH, Campo E, Harris NL et al (eds). WHO classification of tumours of haematopoietic and lymphoid tissues. Geneva: WHO Press 2008: 102– 103.
21. Brunning RD, Hasserjian RP, Porwizt Aet al. Refractory cytopenia with unilineage dysplasia. In: Swerdlow SH, Campo E, Harris NL et al (eds). WHO classification of tumours of haematopoietic and lymphoid tissues. Geneva: WHO Press 2008: 94– 97.
Labels
Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
2010 Issue Supplementum 1
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