Autoimmune haemolytic anaemias
Authors:
L. Raida
Authors‘ workplace:
Přednosta: Prof. MUDr. Karel Indrák, DrSc.
; Lékařská fakulta Univerzity Palackého a Fakultní nemocnice Olomouc, Hemato-onkologická klinika
Published in:
Prakt. Lék. 2011; 91(2): 82-84
Category:
Various Specialization
Overview
Autoimmune haemolytic anaemias (AIHA) belong to the acquired diseases with increased consumption of red cells. Autoantibodies bound to the red cells antigens provide an intravascular and/or extravascular haemolysis mediated by monocyte-macrophage system and/or complement. AIHA can be divided into the ones:
1) AIHA with warm-reacting antibodies,
2) AIHA with cold agglutinins,
3) mixed type,
4) paroxysmal cold haemoglobinuria, and
5) drug-related immune haemolytic anaemias.
Except the general markers of haemolysis, the diagnosis is determined by the recognizing of anti-erythrocyte antibodies.
The treatment and its efficacy depend on the type of AIHA. The major aim of therapy is to suppress the activity of autoimmune mechanism leading to the clinically significant haemolysis.
Key words:
autoimmune haemolytic anaemia, anti-erythrocyte autoantibodies, diagnostics, treatment.
Sources
1. Abramson, N., Gelfand, E.W., Jandl, J.H., Rosen, F.S. The interaction between human monocytes and red cells: specificity for IgG subclasses and IgG fragments. J. Exp. Med. 1970, 132, p. 1207-1215.
2. Ahrens, N., Kingreen, D., Seltsam, A. et al. Treatment of refractory autoimmune haemolytic anaemia with anti-CD20 (rituximab). Br. J. Haematol. 2001, 114, p. 244-245.
3. Ehlenberger, A.G., Nussenzweig, V. The role of membrane receptors for C3b and C3d in phagocytosis. J. Exp. Med. 1977, 145, p. 357-371.
4. Gehrs, B.C., Friedberg, R.C. Autoimmune hemolytic anemia. Am. J. Haematol. 2002, 69, p. 258-271.
5. Heczko, M. Autoimunitní hemolytické anémie (AIHA). In: Indrák, K., a kol. Hematologie. Praha/Kroměříž: Triton 2006.
6. Heddle, N.M. Acute paroxysmal cold hemoglobinuria. Transfus. Med. Rev. 1989, 3, p. 219-229.
7. Horwitz, C.A., Moulds, J., Henle, W. et al. Cold agglutinins in infection mononucleosis and heterophil-antibody-negative mononucleosis-like syndromes. Blood 1977, 50, p. 195-200.
8. Horwitz, C.A., Skradski, K., Reece, E. et al. Haemolytic anaemia in previously healthy adult patients with CMV infections: report of two cases and an evaluation of subclinical haemolysis in CMV mononucleosis. Scand. J. Haematol. 1984, 33, p. 35-42.
9. Lechner, K., Jäger, U. How I treat autoimmune haemolytic anemias in adults. Blood 2010, 116, p. 1831-1838.
10. Lee, E.J., Kueck, B. Rituxan in the treatment of cold agglutinin disease. Blood 1998, 92, p. 3490-3491.
11. Plapp, F., Beck, M.L. Transfusion support in the management of immune hemolytic disorders. Clin. Haematol. 1984, 13, p. 167-183.
12. Reusser, P., Osterwalder, B., Burri, H., Speck, B. Autoimmune haemolytic anemia associated with IgA – diagnostic and therapeutic aspects in a case with long-term follow-up. Acta Haematol. 1987, 77, p. 53-56.
13. Roelcke, D. Cold agglutination. Transfus. Med. Rev. 1989, 3, p. 140-166.
14. Rose, W.F., Adams, J.P. The variability of haemolysis in the cold agglutinin syndrome. Blood 1980, 56, p. 409-416.
15. Salama, A., Mueller-Eckhardt, M. Autoimmune haemolytic anaemia in childhood associated with non-complement binding IgM autoantibodies. Br. J. Haematol. 1987, 65, p. 67-71.
16. Shulman, I.A., Branch, D.R., Nelson, J.M., et al. Autoimmune haemolytic anemia with both cold and warm autoantibodies. J. Am. Med. Assoc. 1985, 253, p. 1746-1748.
17. Sokol, R.J., Booker, D.J., Stamps, R. The pathology of autoimmune haemolytic anemia. J. Clin. Pathol. 1992, 45, p. 1047-1052.
18. Worlledge, S.M. Immune drug-induced haemolytic anemias. Semin. Haematol. 1969, 6, p. 181-200.
Labels
General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
2011 Issue 2
Most read in this issue
- Antiaggregation treatment – review of drugs, importance for clinical practice, and possibilities of determination of resistance to treatment
- Autoimmune haemolytic anaemias
-
Basics of social cognitive and affective neuroscience.
II. Empathy - Pulmonary embolism as a paraneoplastic symptom of choroid melanoma