Gliosarkóm s komponentou pripomínajúcou alveolárny rabdomyosarkóm: popis prípadu s doposiaľ nepopísanou sarkómovou zložkou
Authors:
M. Švajdler jr. 1; B. Rychlý 2; M. Gajdoš 3; F. Pataky 3; L. Fröhlichová 1; A. Perry 4
Authors‘ workplace:
Department of pathology UNLP Košice, Slovakia
1; Cytopathos, spol. s. r. o., Bratislava, Slovakia
2; Department of neurosurgery UNLP and P. J. Safarik University, Faculty of Medicine Košice, Slovakia
3; Department of Pathology, Division of Neuropathology, University of California, San Francisco, USA
4
Published in:
Čes.-slov. Patol., 48, 2012, No. 4, p. 210-214
Category:
Original Articles
Overview
Gliosarkóm (GS) je relatívne vzácny variant glioblastómu, charakterizovaný bifázickou gliálnou a mezenchymálnou diferenciáciou. Sarkomatózna časť najčastejšie pripomína fibrosarkóm alebo tzv. malígny fibrózny histiocytóm. Vzácne je v GS prítomná heterológna diferenciácia vo forme osteosarkómu, chondrosarkómu, liposarkómu, leiomyosarkómu, skvamóznej alebo žľazovej malígnej epiteliálnej diferenciácie, alebo diferenciácie pripomínajúcej primitívny neuroektodermálny tumor (PNET). Keď je v GS prítomná rabdomyosarkómová diferenciácia, je vo forme malígnych vretenovitých buniek s priečne pruhovanými bunkami alebo okrúhlymi rabdomyoblastami, pripomínajúca embryonálny rabdomyosarkóm. V kazuistike popisujeme GS s komponentou pripomínajúcou alveolárny rabdomyosarkóm. Nádor rástol v solídnych a alveolárnych formáciách a bol zložený z nediferencovaných primitívnych malých okrúhlych buniek s minimálnou cytoplazmou, nápadne zvýšenou mitotickou aktivitou a početnými apoptózami. Rabdomyosarkomatózna diferenciácia bola potvrdená pozitívnou imunohistochemickou reakciou na dezmín a myogenín. Podľa naších vedomostí, takýto histologický vzor nebol v GS doposiaľ popísaný. V krátkosti je prebraná diferenciálna diagnóza prípadu.
Kľúčové slová:
gliosarkóm – alveolárny rabomyosarkóm – myogenín - desmín
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Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
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