Pseudotumors of the central nervous system
Authors:
J. Zámečník 1; L. Mrázková 2
Authors‘ workplace:
Ústav patologie a molekulární medicíny, 2. LF UK a FN Motol, Praha
1; Klinika zobrazovacích metod, 2. LF UK a FN Motol, Praha
2
Published in:
Čes.-slov. Patol., 48, 2012, No. 4, p. 184-189
Category:
Reviews Article
Overview
The histopathological differentiation of the pseudoneoplastic lesions from the tumors of the central nervous system (CNS) is not easy in a proportion of cases and the risk of diagnostic misinterpretation in biopsies of the CNS remains relatively high. Here we discuss selected CNS lesions, which can be easily mistaken for a tumor, particularly in the absence of relevant clinical and neuroradiological data - gliosis, tumefactive demyelination, radionecrosis and focal cortical dysplasia. With the exception of the recently available IDH1 immunohistochemistry, there is a lack of simple and reliable histochemical or molecular markers which could facilitate this differential diagnosis. To avoid a diagnostic error, pathologists have to rely on careful microscopic analysis along with its correlation with clinical data and neuroradiological findings.
Keywords:
pseudotumor – brain biopsy – glioma – gliosis – demyelination – radionecrosis
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Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
2012 Issue 4
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