News in the classification of pulmonary adenocarcinomas and potential prognostic and predictive factors in non-small lung cancer
Authors:
Škarda J.ihash2ihash4ihash6 1 1 1 2
Authors‘ workplace:
Ústav klinické a molekulární patologie a Laboratoř molekulární patologie LF UP a FN Olomouc, Oddělení patologie a molekulární medicíny, Fakultní Thomayerova nemocnice s poliklinikou, Praha
1
Published in:
Čes.-slov. Patol., 47, 2011, No. 4, p. 168-172
Category:
Reviews Article
Overview
Lung cancers are still divided into two major subgroups:
small-cell and non-small cell lung cancer (NSCLC) irrespective of biological heterogeneity of NSCLC. It is a key task of the pathologist to provide an accurate classification of tumorous lesions to avoid the term NSCLC and to use it only in the vast minority of cases. Moreover, the most recent reclassification of pulmonary adenocarcinomas should be reflected in the standard biopsy protocol reporting. There is also an increasingly urgent need to provide high quality material for testing of the genetic characteristics of NSCLC, especially the presence and functional status of the EGFR receptor (epidermal growth factor receptor), as well as other potential prognostic markers. The requirement for the quality and swiftness of diagnosis puts major emphasis on the close multidisciplinary collaboration with the central role of a specialized pathologist, who coordinates the differential-diagnostic procedure. This in turn implies the necessity of accounting for the increasing financial burden of diagnostic departments.
Keywords:
lung cancer – adenocarcinoma – classification – prognostic factors – EGFR
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Czecho-Slovak Pathology
2011 Issue 4
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