Carney complex
Authors:
D. Kacerovská 1,2; M. Michal 1,2; R. Šíma 1,2; P. Grossmann 1,2; D. V. Kazakov 1,2
Authors‘ workplace:
Šiklův patologický ústav, FN a LF UK, Plzeň
1; Bioptická laboratoř s. r. o., Plzeň
2
Published in:
Čes.-slov. Patol., 47, 2011, No. 4, p. 192-197
Category:
Reviews Article
Overview
Carney complex is a clinically and genetically heterogeneous disease, with at least two genetic loci including the PRKAR1A gene located on chromosome 17 and the CNC2 locus mapped to chromosome 2. Clinically this syndrome is characterized by multiple myxomas occurring in different anatomic sites, mucocutaneous pigmentary lesions, and a variety of non-endocrine and endocrine tumors, often causing endocrine abnormalities, involving various organs.
Knowledge of morphological findings in CNC patients with their typical locations is necessary to raise suspicion of this syndrome by pathologists. Confirmation of the diagnosis allows regular clinical check-ups and early treatment of these patients.
Keywords:
Carney complex – cutaneous myxoma – cardiac myxoma – primary pigmented nodular adrenocortical disease – large-cell calcifying Sertoli cell tumor – psammomatous melanotic schwannoma – PRKAR1A gene – CNC2 locus
Sources
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Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
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