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Cytogenetics of acute leukemias in childhood


Authors: D. Ilenčíková
Authors‘ workplace: 2. detská klinika LFUK a DFNsP, Bratislava, prednosta prof. MUDr. L. Kovács, DrSc., MPH
Published in: Čes-slov Pediat 2015; 70 (2): 93-98.
Category: Acute leukemias in children

Overview

Acute childhood leukemias are characterized by recurrent numerical and structural chromosomal anomalies, which are specifically associated with diagnosis and prognosis of childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The identification of chromosomal aberrations is clinically very important for oncological praxis to distribute patients in to the diverse risk groups. However there have been a group of patients with undetectable genetic marker, possibly due to the low resolution of used genetic screening tools.

This review present the most chromosomal aberrations associated with pediatric ALL and AML and their clinical significance, as well as the current technologies used for their identification.

Key words:
cytogenetic analysis, acute lymphoblastic leukemia, acute myeloid leukemia


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Neonatology Paediatrics General practitioner for children and adolescents
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