Vitamin D – an Old Vitamin from a New Perspective
Authors:
J. Ferenczová; Ľ. Podracká
Authors‘ workplace:
I. Klinika detí a dorastu LF UPJŠ, Košice
prednostka prof. MUDr. Ľ. Podracká, CSc.
Published in:
Čes-slov Pediat 2009; 64 (7-8): 344-351.
Category:
Review
Overview
Vitamin D is an essential hormone with a substantial antirachitic effect. In addition to its important role in the homeostasis of calcium and phosphorus, over the last years many physicians have also been focusing on the noncalcemic actions of vitamin D (immunomodulatory, antiproliferative, effect on the blood pressure regulation, etc.). In a review article, the authors summarise the latest information on the physiological effect of vitamin D and its relation to autoimmune and civilization diseases.
The authors point out the significance of 25-hydroxyvitamin D determination in a serum which serves as a “barometer” of vitamin D reserves in the body in order to achieve the optimal supplementation. They re-evaluate the current recommendation in the prevention of vitamin D deficiency and present practical instructions to be used in serving cholecalciferol in 600-800 IU/day dosage from the second week to the third year of a child. An adequate intake of calcium is a part of the hypovitaminosis D prevention.
Key words:
vitamin D, calcium homeostasis, noncalcemic actions of vitamin D, vitamin D deficiency, calcidiol, calcitriol, vitamin D requirements, infants, children, adolescents
Sources
1. Rajakumar K. Vitamin D, cod-liver oil, sunlight, and rickets: a historical perspective. Pediatrics 2003;2: 132–135.
2. Holick M. Resurrection of vitamin D deficiency and rickets. J. Clin. Invest. 2006;8: 2026–2072.
3. Gartner M, Greer F, et al. Prevention of rickets and vitamin D deficiency: new guidelines for vitamin D intake. Pediatrics 2003;4: 908–910.
4. Roux C, Bischoff-Ferrari HA, Papapoulos SE, et al. New insights into the role of vitamin D and calcium in osteoporosis management: an expert roundtable discussion. Cur. Med. Res. Opin. 2008;24(5): 1363–1370.
5. Dusso A, Brown AJ, Slatopolsky E. Vitamin D. Am. J. Physiol. Renal. Physiol. 2005;289(1): F8–28.
6. Holick M. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers and cardiovascular disease. Am. J. Clin. Nutr. 2004;4: 1678S–1688S.
7. Bayer M. Vitaminy rozpustné v tucích. Praktické Lékárenství 2008;4(5): 235–237.
8. Clemens T, Henderson L, Adams S, et al. Increased skin pigment reduced capacity of skin to synthesis vitamin D3. Lancet 1982;1: 74–76.
9. Holick MF, Matsuoka LY, Wortsman J. Age, vitamin D and solar ultraviolet. Lancet 1989;2: 1104–1105.
10. Bouillon R, Moody T, Sporn M, et al. NIH deltainoids meeting on vitamin D and cancer. Conclusion and strategic options. J. Steroid. Biochem. Mol. Biol. 2005;97(1–2): 3–5.
11. Valdivielso J, Fernandez E. Vitamin D receptor polymorphism and diseases. Clin. Chim. Acta 2006;1: 1–12.
12. Bayer M, Kutílek Š, et al. Metabolická onemocnění skeletu u dětí. 1. vyd. Praha: Grada, 2002: 1–340.
13. Wilczek H. Současnost vitaminu D. Čes.-slov. Pediat. 1999;4: 197–199.
14. Xue Y, Karaplis AC, Hendy GN, et al. Exogenous 1,25-dihydroxyvitamin D3 exerts a skeletal anabolic effect and improves mineral ion homeostasis in mice that are homozygous for both the 1α-hydroxylase and parathyroid hormone null alleles. Endocrinology 2006;147: 4801–4810.
15. Griffin M, Xing N, Kumar A. Vitamin D and its analogs as regulators of immune activation and antigen presentation. Annu. Rev. Nutr. 2003;2: 117–145.
16. Hewison M, Yehnder D, Chakraverty R, et al. Vitamin D and barrier function: a novel role for extra-renal 1α-hydroxylase. Mol. Cell. Endocrinol. 2004;2: 13–19.
17. Kalvachová B. Vitamin D – nové poznatky a endokrinní mikrosystémy kalcitriolu. Osteologický Bulletin 2007;2: 62–67.
18. Borissova A, Tankova T, Kirilov G, et al. The effect of vitamin D3 on insulin secretion and peripherial insulin sensitivity in type 2 diabetic patients. Int. J. Clin. Pract. 2003;4: 258–261.
19. Hypponen E, Laara E, Jarvelin M. Intake of vitamin D and risk of type 1 diabetes: a birth cohort study. Lancet 2001;358: 1500–1503.
20. Norris JM. Can the sunshine vitamin shed light on type 1 diabetes? Lancet 2001;358: 1476–1477.
21. Stene LC, Joner G. Norwegian childhood diabetes study group. Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study. Am. J. Clin. Nutr. 2003;78: 1128–1134.
22. Cinek O. Etiologie dětského diabetes mellitus 1. typu. In: Perušičová J. Diabetes mellitus 1. typu. 2. vyd. Praha: Geum, 2008: 47–72.
23. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am. J. Clin. Nutr. 2008;87(suppl): 1080S–1086S.
24. Janda J, Bláhová K. Nepříznivý efekt vysokých profylaktických dávek vitaminu D na ledviny (přehled). Čes.-slov. Pediat. 1998;Suppl 1: 29–30.
25. Sedláčková K, Kovács L, Petríková I, et al. Prevencia hypovitaminózy D a rachitídy – ako a čím? Det. Lek. 1995;2: 32–35.
26. Bayer M. Preventivní podávání vitaminu D u dětí – současné názory na dávkování. Čes.-slov. Pediat. 2000;1: 48–50.
27. Bayer M. Rachitis v ordinaci praktického lékaře. Čes.-slov. Pediat. 1999;4: 208–211.
28. Ziegler E, Hollis B, Nelson S, et al. Vitamin D deficiency in breastfed infants in Iowa. Pediatrics 2006;8: 603–610.
29. Kruse A. Aktuelle aspekte der vitamin D-mengel rachitis. Monatschr. Kinderheilkd. 2000;148(6): 588–595.
30. Ferenczová J, Behúnová J, Podracká Ľ, et al. Je rachitída u našich detí zriedkavá? Det. Lek. 2003;3: 7–10.
31. Prentice A, Schoenmakers I, Laskey MA, et al. Nutrition and bone growth and development. Proc. Nutr. Soc. 2006;65(4): 348–360.
32. Wagner CL, Greer FR, et al. Prevention of rickets and vitamin D deficiency in infants, children and adolescents. Pediatrics 2008;122: 1142–1152.
33. Hochberg Z, Bereket A, Davenport M, et al. Consensus development for the supplementation of vitamin D in childhood and adolescence. Horm. Res. 2002;58: 39–51.
34. Bischoff-Ferrari HA, Giovannucci E, Willett WC, et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am. J. Clin. Nutr. 2006;84: 18–28.
35. Dawson-Hughes B, Heaney RP, Holick MF, et al. Estimates of optimal vitamin D status. Osteoporos. Int. 2005;16(7): 713–716.
36. Houghton L, Vieth R. The case against ergocalciferol (vitamin D2) as a vitamin supplementation. Am. J. Clin. Nutr. 2006;84: 694–697.
37. Greer F. Issues in establishing vitamin D recommendations for infants and children on vitamin D and health in the 21st century: bone and beyond. Am. J. Clin. Nutr. 2004;6: 1759–1762.
38. Doets EL, deWit LS, Dhonukshe-Rutten RAM, et al. Current micronutrient recommendations in Europe: towards understanding their differences and similarities. Eur. J. Nutr. 2008;47(Suppl 1): 17–40.
39. Wharton B, Bishop N. Rickets. Lancet 2003;10: 1389–1400.
Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2009 Issue 7-8
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