DRESS syndrome

Česká verze

Authors: Monika Adamcová; Igor Šturdík; Tomáš Koller; Juraj Payer
Authors place of work: V. interná klinika LF UK a UN Bratislava, Nemocnica Ružinov, Slovenská republika
Published in the journal: Vnitř Lék 2016; 62(4): 334-337
Category: Kazuistiky

Summary

DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is severe drug-induced allergic-type reaction which occurs few days to weeks after taking a drug in a predisposed patient. Organ damage, eosinophilia and skin rash are typical at presentation. Corticotherapy is often necessary in severe cases. In this report we describe a case of 56-year old female with fever, elevated liver tests and skin rash. DRESS syndrome was diagnosed and allopurinol was indentified as a causative drug. Due to possible fatal outcome, DRESS syndrome should be considered in a differential diagnosis of all patients presenting with similar signs and symptoms.

Key words:
allopurinol – DRESS syndrome – hepatopathy

Zdroje

1. Bocquet H, Boagot M, Roujeau JC. Drug-induced pseudolymphoma and drug hypersensitivity (Drug rash with eosinophilia and systemic symptoms: DRESS). Sem Cutan Med Surg 1996; 15(4): 250–257.

2. Cacoub P, Musette P, Descamps V et al. The DRESS syndrome: a literature review. Am J Med 2011; 124(7): 588–597.

3. Criado PR, Criado RFJ, Avancini J et al. Drug reaction with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS): a review of current concepts. An Bras Dermatol 2012; 87(3): 435–449.

4. Walsh SA, Creamer D. Drug reaction with eosinophila and systemic symptoms (DRESS): a clinical update and review of current thinking. Clin Exper Dermatol 2011; 36(1): 6–11.

5. Husain Z, Reddy BY, Schwartz RA. DRESS syndrome: Part I. Clinical perspectives. J Am Acad Dermatol 2013; 68(5): 693. e1–14; quiz 706–8. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jaad.2013.01.033>.

6. Criado PR, Avancini J, Santi CG et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): a complex interaction of drugs, viruses and the immune system. Isr Med Assoc J 2012; 14(9): 577–582.

7. Descamps V, Ranger-Rogez S. DRESS syndrome. Joint Bone Spine 2014; 81(1): 15–21.

8. Shiohara T, Inaoka M, Kano Y. Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses. Allergol Int 2006; 55(1): 1–8.

9. Karásek D, Vymětal J, Cibíčková L et al. DRESS syndrom vzniklý při léčbě alopurinolem. Klin Farmakol Farm 2014; 28: 152–157.

10. Hrubiško M et al. Alergológia. Osveta: Martin 2003: 391–394. ISBN 80–8063–110–7.