Průtoková cytometrie u monoklonálních gamapatií
Autoři:
L. Kovářová 1,2; T. Varmužová 1,2; P. Zarbochová 3; R. Suská 1; Muthu Raja K. R. 2,4; J. Štossová 2; M. Penka 4; R. Hájek 1,2,5
Působiště autorů:
Laboratory of Experimental Hematology and Cell Immunotherapy, Department of Clinical Hematology, University Hospital Brno, Czech Republic
1; Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
2; Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
3; Department of Clinical Hematology, University Hospital Brno, Czech Republic
4; Department of Internal Medicine – Hematooncology, University Hospital Brno, Czech Republic
5
Vyšlo v časopise:
Klin Onkol 2011; 24(Supplementum 1): 24-29
Souhrn
Technologický rozvoj průtokové cytometrie (flow cytometry, FC) spolu s nejnovějšími poznatky z oblasti imunofenotypizace monoklonálních gamapatií (MG) odhalil nezbytnost tohoto vyšetření zejména pro jeho diagnostický, prognostický a prediktivní význam. Cílem Evropské myelomové sítě (European Myeloma Network, EMN) je standardizovat tuto analytickou metodu a zařadit ji mezi rutinní klinická vyšetření. Jelikož celkový význam a možné aplikace FC jsou stále analyzovány, je zřejmé, že standardizace může napomoci zisku relevantních klinických výstupů z oblasti patofyziologie MG.
Klíčová slova:
mnohočetný myelom – monoklonální gamapatie – průtoková cytometrie – plazmatická buňka
Tato práce byla podpořena granty Ministerstva školství, mládeže a tělovýchovy: LC06027, MSM0021622434; výzkumnými projekty IGA Ministerstva zdravotnictví: NT12425, NS10406, NS10408 a granty GAČR GAP304/10/1395, GP301/09/P457.
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Štítky
Dětská onkologie Chirurgie všeobecná OnkologieČlánek vyšel v časopise
Klinická onkologie
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Nejčtenější v tomto čísle
- Mnohočetný myelom
- Fenotypizace a kvantifikace T regulačních lymfocytů u pacientů s mnohočetným myelomem pomocí průtokové cytometrie
- Monoklonální gamapatie nejasného významu: Úvod a současné klinické problémy
- Průtoková cytometrie u monoklonálních gamapatií