Serrated adenomas and carcinomas of the colon
Authors:
Alena Chlumská 1,2; Petr Martínek 2; Petr Mukenšnabl 1; Michael Michal 1,2; Michal Zámečník 3,4
Authors place of work:
Šiklův ústav patologie FN, Univerzita Karlova v Plzni, Česká republika
1; Bioptická laboratoř s. r. o., Plzeň, Česká Republika
2; Agel a. s., Laboratoř patologie, Nový Jičín, Česká republika
3; Medirex Group Academy n. o., Bratislava, Slovenská republika
4
Published in the journal:
Čes.-slov. Patol., 52, 2016, No. 1, p. 11-14
Category:
Přehledový článek
Summary
Approximately 5 – 35 % of colorectal carcinomas arise through serrated carcinogenesis. The precursor of such carcinomas are serrated adenomas, which differ from conventional adenomas morphologically as well as genetically. Herein, we provide a basic overview of serrated lesions of the large intestine with the focus on histological diagnosis and molecular biology.
Keywords:
hyperplastic polyp – sessile serrated adenoma – traditional serrated adenoma – serrated carcinoma – serrated carcinogenesis
Zdroje
1. Bettington ML, Walker N, Rosty Ch, et al. A clinicopathological and molecular analysis of 200 traditional serrated adenomas. Mod Pathol 2015; 28: 414-427.
2. Bordacahar B, Barret M, Terris B, et al. Sessile serrated adenoma: from identification to resection. Dig Liver Dis 2015; 47: 95-102.
3. Crowder CD, Sweet K, Lehman A, Frankel WL. Serrated polyposis is an underdiagnosed and unclear syndrome. The surgical pathologist has a role in improving detection. Am J Surg Pathol 2012; 36: 1178-1185.
4. Kwon HJ, Cho NY, Chang MS, Kim YS, Kang GH. Intermediate serrated polyp as an intermediate lesion of hyperplastic polyp and sessile serated polyp/adenoma in terms of morphological and molecular features. Hum Pathol 2014; 45: 1759-1765.
5. Lash RH, Genta RM, Schuler CM. Sessile serrated adenomas: prevalence of dysplasia and carcinoma in 2139 patients. J Clin Pathol 2010; 63: 681-686.
6. O´Brien MJ, Zhao Q, Yang S. Colorectal serrated pathway cancers and precursors. Histopathology 2015; 66: 49-65.
7. Rosty Ch, Buchanan DD, Walsh MD, et al. Phenotype and polyp landscape in serrated polyposis syndrome: A series of 100 patients from genetics clinics. Am J Surg Pathol 2012; 36: 876-822.
8. Snover DC. Update on the serrated pathway to colorectal carcinoma. Hum Pathol 2011; 42: 1-10.
9. Bettington M, Walker N, Clouston A, Brown I, Leggett B, Whitehall V. The serrated pathway to colorectal carcinoma: current concepts and challenges. Histopathology 2013; 62: 367-386.
10. Bettington M, Walker N, Rosty C, et al. Critical appraisal of the diagnosis of the sessile serrated adenoma. Am J Surg Pathol 2014; 38: 158-166.
11. Chlumská A, Boudová L, Zámečník M. Sessile serrated adenomas of the large bowel. Clinicopathologic and immunohistochemical study including comparison with common hyperplastic polyps and adenomas. Cesk Patol 2006; 42: 133-138.
12. Mäkinen MJ. Colorectal serrated adenocarcinoma.Histopathology 2007; 50: 131-150.
13. Salaria SN, Streppel MM, Lee LA, Iacobuzio- Donahue CA, Montgomery EA. Sessile serrated adenomas: high-risk lesions? Hum Pathol 2012; 43: 1808-1814.
14. Snover DC, Ahnen DJ, Burt RW, Odze RD. Serrated polyps of the colon and rectum and serrated polyposis. In: Bosman FT, Carneiro F, Hruban RH, Thiese ND, eds. WHO Classification of Tumors of the Digestive System (4th ed). Lyon: IARC; 2010: 160-165.
15. Yang HM, Mitchell JM, Sepulveda JL, Sepulveda AR. Molecular and histologic considerations in the assessment of serrated polyps. Arch Pathol Lab Med 2015; 139: 730-741.
16. Bettington ML, Chetty R. Traditional serrated adenoma: an update. Hum Pathol 2015; 46: 933-938.
17. Kim MJ, Lee EJ, Suh JP, et al. Traditional serrated adenoma of the colorectum. Clinicopathologic implications and endoscopic findings of the precursor lesions. Am J Clin Pathol 2013; 140: 898-911.
18. Wiland HO, Shadrach B, Allende D, et al. Morphologic and molecular characterization of traditional serrated adenomas of the distal colon and rectum. Am J Surg Pathol 2014; 38: 1290-1297.
19. Hafezi-Bakhtiari S, Wang LM, Colling R, Serra S, Chetty R. Histological overlap between colorectal villous/tubulovillous and traditional serrated adenomas. Histopathology 2015; 66: 308-313.
20. Bettington M, Walker N, Rosty C, et al. Serrated tubulovillous adenoma of the large intestine. Histopathology. In press 2016.
Štítky
Patologie Soudní lékařství ToxikologieČlánek vyšel v časopise
Česko-slovenská patologie
![Číslo 1](https://www.prolekare.cz/media/cache/resolve/journal_issue/media/image_pdf/6275dd07758253005fa153bc3169f54b.jpeg)
2016 Číslo 1
Nejčtenější v tomto čísle
- Serrated adenomy a karcinomy tlustého střeva
- Morfologie gastroezofageálního refluxu
- Folikulový lymfóm a lymfóm z plášťových buniek v biopsiách orgánov žalúdočno-črevnej oblasti
- Kožná bunková reakcia po popálení medúzou