Antibodies Against Glycoconjugates in the Diagnosis of Autoimmune Neuropathies
Authors:
K. Malíčková; I. Janatková; P. Šandová; T. Zima
Authors place of work:
Ústav klinické biochemie a laboratorní
diagnostiky 1. LF UK a VFN, Praha
Published in the journal:
Cesk Slov Neurol N 2007; 70/103(6): 631-636
Category:
Přehledný referát
Summary
Autoimmune neuropathies are immunopathological conditions which can be accompanied by the presence of antibodies against glycoconjugates of neural cell membranes. Autoaggressive reactions are mostly directed against gangliosides and some glycoproteins, for instance against myelin-associated glycoprotein. A relatively precise profile of anti-glycoconjugate auto-antibodies can be defined for a number of inflammatory neuropathies. The testing of antibodies against a wide range of gangliosides and glycoproteins is currently available in clinical laboratory diagnostics, with blot methods, enzyme immunoanalysis and indirect immunofluorescence ranking among the most frequently used techniques. The above methods are cost and time available and can contribute to the detection or specification of diagnosis of neuropathy.
Key words:
autoimmune neuropathy – gangliosides – myelin-associated glycoprotein – autoantibodies – immunoblot – enzyme immunoanalysis – indirect immunofluorescence
Zdroje
1. Ariga T, Miyatake T, Yu RK. Recent studies on the roles of antiglycosphingolipids in the pathogenesis of neurological disorders. J Neurosci Res 2001; 65: 363-370.
2. O'Leary CP, Willison HJ. The role of antiglycolipid antibodies in peripheral neuropathies. Curr Opin Neurol 2000; 13: 583-588.
3. Steck AJ. Auto-antibody tests in peripheral neuropathies: pros and cons. J Neurol 2000; 247:423-428.
4. Caudie C. Monoclonal IgM autoantibody reactivity in M-IgM peripheral neuropathy. Clin Rev Allergy Immunol 2000; 19: 7-18.
5. Willison HJ, Yuki N. Peripheral neuropathies and anti-glycolipid antibodies. Brain 2002; 125: 2591-2625.
6. Klenk E. Über der Gangliosides. Hoppe-Seylers Z Physiol Chem 1942; 273: 276.
7. Svennerholm L. Composition of gangliosides from human brain. Nature 1956; 177: 524-525.
8. Svennerholm L. Ganglioside metabolism. In: Comprehensive Biochemistry, Vol 18. New York: Elsevier 1970: 201-227.
9. Svennerholm L. Ganglioside loss is a primary event in Alzheimer disease type I. Prog Brain Res 1994; 101:391-404.
10. Yuki N. Anti-ganglioside antibody and neuropathy: review of our research. J Peripher Nerv Syst 1998; 3: 3-18.
11. Nobile-Orazio E, Cappellari A, Priori A. Multifocal motor neuropathy: current concepts and controversies.Muscle Nerve 2005; 31: 663-680.
12. Nobile-Orazio E, Terenghi F, Carpo M, Bersano A. Treatment of multifocal motor neuropathy. Neurol Sci 2003; 24(Suppl 4): S251-S255.
13. Schwerer B. Antibodies against gangliosides: a link between preceding infection and immunopathogenesis of Guillain-Barre syndrome. Microbes Infect 2002; 4: 373-384.
14. Prendergast MM, Moran AP. Lipopolysaccharides in the development of the Guillain-Barre syndrome and Miller Fisher syndrome forms of acute inflammatory peripheral neuropathies. J Endotoxin Res 2000; 6: 341-359.
15. Willison HJ. The immunobiology of Guillain-Barre syndromes. J Peripher Nerv Syst 2005; 10: 94-112.
16. Ang CW, Jacobs BC, Laman JD. The Guillain-Barre syndrome: a true case of molecular mimicry. Trends Immunol 2004; 25: 61-66.
17. Komagamine T, Yuki N. Ganglioside mimicry as a cause of Guillain-Barre syndrome. CNS Neurol Disord Drug Targets 2006; 5: 391-400.
18. Yuki N, Odaka M. Ganglioside mimicry as a cause of Guillain-Barre syndrome. Curr Opin Neurol 2005; 18: 557-561.
19. Latov N, Sherman WH, Nemni R, Galassi G, Shyong JS, Penn AS et al. Plasma-cell dyscrasia and peripheral neuropathy with a monoclonal antibody to peripheral-nerve myelin NEJM 1980; 303: 618-621.
Štítky
Dětská neurologie Neurochirurgie NeurologieČlánek vyšel v časopise
Česká a slovenská neurologie a neurochirurgie
![Číslo 6](https://www.prolekare.cz/media/cache/resolve/journal_issue/media/image_pdf/8e5c97450ec97a7aa4e5c8753444918b.jpeg)
2007 Číslo 6
- Metamizol jako analgetikum první volby: kdy, pro koho, jak a proč?
- Nejčastější nežádoucí účinky venlafaxinu během terapie odeznívají
- Moje zkušenosti s Magnosolvem podávaným pacientům jako profylaxe migrény a u pacientů s diagnostikovanou spazmofilní tetanií i při normomagnezémii - MUDr. Dana Pecharová, neurolog
- Pregabalin je účinné léčivo s příznivým bezpečnostním profilem pro pacienty s neuropatickou bolestí
Nejčtenější v tomto čísle
- Obrna lícního nervu
- Poruchy polykání ve vztahu k vertebrogenním dysfunkcím
- Protilátky proti glykokonjugátům v diagnostice autoimunitních neuropatií
- Dercumova choroba (lipomatosis dolorosa) – zriedkavo diagnostikované ochorenie: kazuistika