Nejvýznamnější markery receptivity endometria

English version

Autoři: N. Kushniruk; Tomáš Fait
Působiště autorů: Head of Department prof. MUDr. A. Martan, DrSc. ; Department of Obstetrics and Gyneacology, 1st Faculty of Medicine, Charles University, General Faculty Hospital, Prague
Vyšlo v časopise: Ceska Gynekol 2014; 79(4): 269-275

Souhrn

Cíl studie:
Vyhledat markery nedostatečné kvality endometria.

Typ studie:
Literární přehled.

Pracoviště:
Gynekologicko-porodnická klinika 1. LF UK a VFN Praha.

Výsledky:
Předkládáme přehled faktorů ovlivňujících receptivitu endometria. Data ukazují na význam exprese genů ze skupiny homeobox, zejména HOX10 a HOX 11, které zajišťují proces implantace svojí interakcí s estrogenními a progesteronovými receptory cestou stimulačních proteinů v luteální fázi. Optimální stav sliznice děložní v proliferační fázi je dán přiměřenou sekrecí osteoponinu, kadherinu, selektinu, apolipoproteinu D, mucinu a přiměřenou aktivitou makrofágů.

Závěr:
Receptivita endometria je ovlivněna expresí genů v endometriu současně s aktivitou makrofágů v nitroděložním prostředí.

Klíčová slova:
selhání implantace, receptivita endometria, exprese genů, osteoponin, integrin β3, apolipoprotein D, kadheriny, selektiny, HOX geny

Zdroje

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