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News Effectiveness of the Sonicare For Kids Toothbrush in Preschool Children
A comparative study conducted as part of a graduation thesis in the field of Certified Dental Hygienist offers a comparison of the cleaning effectiveness of a manual toothbrush and a sonic toothbrush in children aged 4−5.5 years. The sonic toothbrush proved to be an effective tool with good results for this age group.
News Efficacy of Sublingual Immunotherapy in Patients with Atopic Dermatitis Sensitized to Dust Mite Allergens
In patients with atopic dermatitis (AD), sensitization to house dust mite allergens is common. According to studies, subcutaneous immunotherapy (SCIT) represents an effective adjunct therapy. The clinical study presented below is one of the few that explored the efficacy of sublingual immunotherapy (SLIT) containing Dermatophagoides pteronyssinus extract.
News What is the Impact of Bisoprolol on Plasma Concentrations of Dabigatran
Many patients on anticoagulant therapy with dabigatran also use the beta-blocker bisoprolol. The Slovak prospective observational study was based on the assumption that bisoprolol, as a significant inhibitor of P-glycoprotein, may interact with dabigatran and focused on examining the effect of this beta-blocker on plasma concentrations of dabigatran.
News Perioperative Management in Patients with Atrial Fibrillation Treated with NOACs
The recommended procedures for perioperative management in patients using novel oral anticoagulants (NOACs) stem from the requirement to minimize treatment interruption before and after surgical procedures to reduce the risk of bleeding and thromboembolism. The safety of these regimens in patients with atrial fibrillation was examined in the prospective PAUSE study presented below.
News Doc. Jitka Fricová: The biggest challenge remains the patient with unbearable chronic pain
Research findings are pushing the boundaries of optimal chronic pain treatment, including better prevention and reduced side effects of analgesics. Algological care is readily accessible in the Czech Republic, yet it faces limitations, such as the less manageable nature of unbearable pain, particularly neuropathic or oncologic. We briefly discuss the topic with the head physician of the Pain Treatment Center at the Department of Anesthesiology, Resuscitation, and Intensive Care Medicine, First Faculty of Medicine, Charles University, and General University Hospital in Prague, Doc. MUDr. Jitka Fricová, Ph.D.
News Metformin and Cardiovascular Disease in Patients with Type 2 Diabetes and Chronic Kidney Disease
Diabetes mellitus is a serious chronic disease that, due to its ever-increasing prevalence, poses a significant problem for society in developed countries. The main cause of morbidity and mortality in patients with type 2 diabetes is cardiovascular disease, and the likelihood of their occurrence is increased by concomitant chronic kidney disease. In current diabetes treatment, antidiabetic agents are thus preferred, as they also provide cardioprotective and nephroprotective effects.
News Micronized Diosmin and Flavonoid Fraction – What Do They Have in Common?
Micronized diosmin and micronized purified flavonoid fraction are medications from the flavonoid group that are used as venopharmaceuticals/venoprotectives in the treatment of chronic venous insufficiency and hemorrhoidal disease. Both have many common properties, which we discuss in the following text. Their differences will be covered in a follow-up article on this topic.
News Innovative Form of Levothyroxine Ensures Accurate Dosing for Patients
In the treatment of hypothyroidism, precise dosing of replacement therapy is critical. An innovative formulation of levothyroxine has been developed to meet the updated, stricter standards of regulatory authorities, thereby ensuring the desired therapeutic effect.
News Sustained Remission of ITP with Thrombopoietin Receptor Agonists Treatment
Thrombopoietin receptor agonists (TPO-RAs) are highly effective drugs administered in chronic immune thrombocytopenia (ITP). Several studies have shown that they can induce remission and long-term response, even after prolonged discontinuation.
News Fixed combination tiotropium/olodaterol in regular clinical practice: What do patients say?
A non-interventional international study assessed the therapeutic benefits of the fixed combination of tiotropium/olodaterol in the treatment of chronic obstructive pulmonary disease (COPD) in real-world practice through a questionnaire filled out by patients.
News Current Legislative Changes Relating to Medical Devices – Overview Summary in a Nutshell
In 2022, several legislative changes were introduced in the area of medical devices (MD) for moist wound care. We are summarizing the news from three sectors, as presented by Mgr. Jan Zahálka at the Interdisciplinary Cooperation in the Treatment of Wounds and Skin Defects congress in 2022: prescribing MD by nurses, European Union Medical Device Regulation (MDR), and the issue of MD as potential hazardous waste.
News Dual therapy improves not only lung function but also quality of life in COPD patients
Chronic obstructive pulmonary disease (COPD) reduces the quality of life of patients and is one of the main causes of morbidity and mortality. According to international recommendations, the initial pharmacotherapy is recommended as monotherapy with LAMA (long-acting muscarinic antagonists) or LABA (long-acting beta-agonists), or their combination. A pooled analysis of 4 studies compared the early addition of LABA to LAMA in patients with moderate to severe COPD.
News Is the combination of tiotropium/olodaterol proven more effective in reducing the risk of clinically significant worsening of COPD compared to monotherapy?
Given the heterogeneity of chronic obstructive pulmonary disease (COPD), the use of a composite parameter that includes lung function, the occurrence of exacerbations, and quality of life offers a more comprehensive view of treatment outcomes. Such a parameter was used in the analysis of the TONADO studies, which compared early use of the fixed combination of tiotropium/olodaterol with tiotropium alone.
News Dust Mite Allergies: Common Does Not Mean Trivial
Dust mite allergies are almost ubiquitous problems that we perceive as part of the 'broader norm.' However, patients do not see it this way, so we should not lose sight of it.
News The Role of Inflammation in the Cardiovascular Continuum and the Aging Process
Inflammation plays a role at various stages of the cardiovascular (CV) continuum, in both atherosclerotic and non-atherosclerotic CV diseases. Where to look for inflammation in the pathophysiology of CV diseases, why inflammation is related to aging, and how to utilize these findings in clinical practice was explained in a lecture by MUDr. Peter Wohlfahrt, Ph.D., from the Center of Preventive Cardiology IKEM in Prague, at the XXXII Annual Meeting of the Czech Cardiology Society.
News How and with What the National Registry of Primary Immunodeficiencies Benefits Specialists and Patients
Primary immunodeficiencies constitute a very heterogeneous group of congenital diseases. They affect both specific and nonspecific immunity and are classified accordingly. The care for patients with antibody production disorders and hereditary angioedema (HAE) is economically the most demanding and relatively specific. Can a specialized registry help improve this care?
News ESC 2022: Evidence of SGLT2i Effectiveness in HFrEF Treatment is Growing: How to Integrate Them into Routine Practice?
Although the need for pharmacotherapeutic options for patients with heart failure with reduced left ventricular ejection fraction (HFrEF) is essential, challenges in implementing this medication according to guidelines persist. This issue was also discussed at a symposium held as part of this year's European Society of Cardiology Congress (ESC 2022).
News Diagnosing Myelodysplastic Syndrome According to MDS Europe
In 2021, the European Hematology Association (EHA) endorsed the recommendations of the MDS Europe group for the diagnosis of myelodysplastic syndrome (MDS). MDS-RIGHT is a large European project aimed at providing the right care to the right patients with MDS at the right time, based on clinically evidenced recommendations.
News Venetostart – The First Comprehensive Mobile Application with Practical Information for Venetoclax Treatment
Abbvie has developed the comprehensive mobile application Venetostart with practical information needed in clinical practice for administering venetoclax (Venclyxto), which is indicated for the treatment of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML).
News Is Adding Fibrinogen Concentrate to Transfusion Therapy for Postpartum Hemorrhage an Effective Approach?
Significant postpartum hemorrhage can be managed with fresh frozen plasma transfusion. However, administering larger volumes is associated with several risks. The authors of the Japanese study below investigated whether fibrinogen concentrate added to fresh frozen plasma transfusions is an effective tool in reducing the need for erythrocyte concentrate and whether it helps prevent complications of intensive transfusion therapy.
News Efficacy and Safety of Gene Therapy Using Adeno-Associated Virus Vector in Patients with Choroideremia
Choroideremia (CHM) is a rare genetically conditioned retinal disease caused by mutations in the CHM gene, leading to a lack of production of the protein REP1 (ras-associated binding escort protein 1). Currently, there is no approved treatment for CHM. The aim of the study (Tübingen Choroideremia Gene Therapy) published last year in the journal JAMA Ophthalmology was to evaluate the safety and efficacy of subretinally applied gene therapy using an adeno-associated virus vector (AAV2), designed to deliver a functional copy of the CHM gene to patients with choroideremia.