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News Deep stimulation of the globus pallidus improved clinical symptoms in a patient with refractory parkinsonism and genetic mutation

The authors of the presented work studied the effects of deep brain stimulation (DBS) in a patient with Parkinson's disease with a genetic mutation that manifests in early adulthood.

Source: Parkinson's Disease 2. 12. 2020

Články časopisu Utilization of Prostate Health Index in prediction of prostate cancer aggressiveness

Author of the article: P. Brož, O. Dolejšová, R. Fuchsová, O. Topolčan, J. Racek, H. Sedláčková, O. Hes, V. Eret, L. Pecen, M. Hora, R. Kučera Source: Klinická biochemie a metabolismus | 1/2019 1. 3. 2019

News Risks Associated with Higher Residual Concentrations of Dabigatran in Seniors and Their Prevalence

Dabigatran is a direct thrombin inhibitor indicated for patients across the age spectrum. The benefit-risk assessment of anticoagulation is individual and depends on many factors. A Dutch observational pilot study examined residual concentrations of dabigatran in seniors of different ages with atrial fibrillation to clarify the relationship between study results and clinical practice.

Source: Anticoagulant Treatment 8. 9. 2022

News Population Pharmacokinetic Model in Patients with von Willebrand Disease

Dutch authors presented a potential population pharmacokinetic model describing levels of von Willebrand factor and coagulation factor VIII during and after surgical procedures in patients with von Willebrand disease.

Source: Von Willebrand Disease 14. 11. 2022

News Prevention of Skeletal Events in the Therapy of Patients with Advanced Prostate Cancer

Prostate cancer most commonly forms metastases in the bones. In patients with this advanced disease, skeletal events occur, negatively affecting their quality of life. Zoledronic acid and denosumab are used to prevent their occurrence, and their results in this indication were evaluated and compared in the cited study below.

Source: Prevention of Bone Events 9. 4. 2022

News Two Current Perspectives on the Importance of (Par)enteral Nutrition in Cancer Patients

Adequate (par)enteral nutrition is crucial for cancer patients in terms of prognosis and quality of life. The following recent studies examined parenteral nutrition as an alternative to ileostomy in patients with colorectal anastomosis and muscle mass loss in patients with metastatic cancer.

Source: Parenteral Nutrition 14. 11. 2022

News Are SGLT2 Inhibitors Only Suitable for the Treatment of Diabetes?

SGLT2 inhibitors, or gliflozins, are effective antidiabetic drugs that have shown nephroprotective and cardioprotective effects in diabetics, repeatedly demonstrated in clinical trials. At the European Cardiology Congress in September 2019 in Paris, results were presented from the DAPA-HF study, where dapagliflozin became the first SGLT2 inhibitor to show benefits in patients with heart failure with reduced ejection fraction of the left ventricle, regardless of whether they had type 2 diabetes or not. The study thus offered a completely new perspective on the treatment of heart failure.

Source: Modern Treatment of Diabetes 19. 2. 2020

News How trends in sports evolve among hemophiliacs and to what extent they are limited by their disease

Historically, physical activity was generally not recommended for hemophiliacs; however, with evolving treatment options and prophylaxis as the gold standard of care for these patients, sports have become part of their lives in recent years. The Netherlands, traditionally supportive of sports, including for patients with chronic illnesses, presented the results of a survey on hemophilia and sports in a poster presentation at the 13th annual EAHAD congress in The Hague this February.

Source: Quality Life Even with Hemophilia 14. 2. 2020

News Does the Risk of Recurrence of Differentiated Thyroid Carcinoma Differ by Gender?

Differentiated thyroid carcinomas (DTC) are typically diagnosed at more advanced stages in men than in women, and mortality from this disease is higher among men than women. However, it was not entirely clear whether the risk of DTC recurrence is influenced by the patient's gender independently of the disease stage at the time of diagnosis. The aim of the Canadian authors' study was to assess whether male gender is an independent risk factor for DTC recurrence.

Source: Thyroid Disorders 14. 2. 2020

News ERS 2022: What Insights Do Studies Focused on COPD Biomarkers Bring?

In this year's scientific program of the international congress of the European Respiratory Society (ERS 2022), there was also a lot of talk about the investigation of biomarkers of chronic obstructive pulmonary disease (COPD) and its acute exacerbations (COPD AE). This topic was also well-represented in the e-poster presentations section. From that section, we select 3 studies whose conclusions are summarized below.

Source: Cough Therapy 1. 11. 2022

News Does Emicizumab Change Routine Clinical Practice?

With the increasing number of patients with hemophilia A being treated with emicizumab, the question arises whether its use in any way changes established clinical practice. A team of American authors sought answers based on a survey conducted among the treating physicians of these patients. The findings were presented at the 13th Annual EAHAD Congress, which took place at the beginning of February in The Hague, Netherlands.

Source: Quality Life Even with Hemophilia 11. 2. 2020

News IEC 2023: Key Challenges for Epilepsy Patients Include Status Epilepticus and Anxiety Management

Why is anxiety a significant issue for epilepsy patients? What do current insights say about the connection between epilepsy and anxiety? Can artificial intelligence be used to predict status epilepticus (SE)? And what is known about the development of late epilepsy following new SE? These and other topics were discussed in September 2023 in Dublin during the 35th International Epilepsy Congress (IEC 2023).

Source: Quick aid for acute convulsive seizures in children and adolescents 21. 2. 2024

News Does the emergence of resistance to cetuximab mean ineffectiveness of all anti-EGFR antibodies?

Colorectal cancer (CRC) cells respond to targeted therapy in different ways. Besides the desired outcome of cell death, CRC cells can adapt and survive through changes in their genome. It is important to recognize that the developed resistance to targeted therapy may, but does not necessarily, apply uniformly across a class of drugs or a single mechanism of action.

Source: Colorectal Cancer 12. 11. 2021

News Clinical Profile and Outcomes of Patients with Cardiac Amyloidosis –⁠ Spanish Experience from Real Practice

Cardiac amyloidosis is caused by the deposition of amyloid fibrils in the myocardium and is among the diseases with significant diagnostic delay. Physicians from the University Hospital in Madrid shared their experiences with the diagnosis and treatment of these patients over the last decade in the cited work below.

Source: Amyloidosis 14. 6. 2023

News Nonacog Beta Pegol (N9-GP) in Bleeding Prophylaxis in Patients with Hemophilia B –⁠ Real World Data

The goal of hemophilia B treatment is currently the prevention of bleeding by administering a coagulation factor IX concentrate. The study presented below brings recent real-world data on treatment outcomes when switching to the latest preparation, nonacog beta pegol (N9-GP).

Source: Hemophilia with Movement 13. 6. 2023