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Journal articles Fertility preserving methods in women with breast cancer before gonadotoxic therapy
News Prolonged Course of Metastatic Stomach Cancer with Long-term Stabilization – Case Report
In the following case report, we present the case of a patient with a prolonged oncological disease – stomach cancer. The patient has been asymptomatic for a long time and in good performance status despite multiple lung metastases, thanks to stabilization with trifluridine/tipiracil treatment.
News How Does the Long-Term Effect of Beta Blocker Use Affect Clinical Outcomes in Patients After Myocardial Infarction?
In patients after myocardial infarction (MI), beta blockers (BB) still hold an important place in secondary prevention according to recommended procedures. However, the question could be their long-term effect on clinical outcomes, as different results can be found in the literature – this fact led the authors of the work cited below to perform a systematic review and meta-analysis of studies dedicated to this issue.
News Innovative Form of Levothyroxine Ensures Accurate Dosing for Patients
In the treatment of hypothyroidism, precise dosing of replacement therapy is critical. An innovative formulation of levothyroxine has been developed to meet the updated, stricter standards of regulatory authorities, thereby ensuring the desired therapeutic effect.
News Cardiovascular System Affection in Children with Noonan Syndrome
Noonan syndrome is a genetically conditioned disease classified among the so-called RASopathies, caused by a germline mutation in the genes of the RAS/MAPK signaling pathway. Among other things, children with this disease typically present with cardiovascular system involvement.
News Use of Testosterone Level as a Biomarker for Quality of Life in Patients with Prostate Cancer
In the treatment of prostate cancer, in addition to surgical treatment, stereotactic body radiotherapy (SBRT) and hormone therapy are also used. Androgen deprivation therapy (ADT) blocks the action or production of male sex hormones and is indicated for the treatment of intermediate and high-risk prostate cancers, where it reduces the risk of metastasis and prolongs survival. The work of experts from several American institutions monitored testosterone levels during therapy and their connection to the development of quality of life scores.
News What Benefits Does the Fixed Combination of Candesartan/Amlodipine Bring?
A relatively new fixed combination used in the treatment of hypertension is represented by candesartan/amlodipine, that is, a sartan and a calcium channel blocker. Its advantage compared to the combination of ACE inhibitor/calcium channel blocker is primarily the lower occurrence of side effects.
News Pathogenetic Mechanisms Underlying the Development and Progression of Interstitial Lung Diseases
Interstitial lung processes (ILP) represent an umbrella term for a wide range of nosological units that differ from each other in clinical course, prognosis, and pathogenesis. Most ILPs are characterized by inflammation or fibrosis of the interstitial space, leading to impaired gas exchange at the alveolocapillary membrane.
News Three tests to confirm the diagnosis of acquired hemophilia – infographic
Acquired hemophilia (AHA) typically manifests with spontaneous bleeding in patients with no prior personal history of significant bleeding.1–4 The cause of the bleeding is a significant decrease in FVIII activity induced by autoantibodies against coagulation factor VIII.5 In polymorbid patients, established antithrombotic therapy at the time of AHA diagnosis may also contribute to the bleeding.4
News Diagnosis and Management of Therapy for a Breastfeeding Patient with Significant Elevation of Liver Enzymes Postpartum – Interactive Case Study
In the following case study, we present a specific approach to a patient who developed a significant elevation of liver enzymes after childbirth. Through interactive elements, you can try out how you would proceed in diagnosing and treating this case.
News Previous Treatment of Osteoporosis May Affect the Efficacy of Romosozumab
A study conducted by a team of authors from several clinical sites in Japan shows that the type and duration of previous osteoporosis treatment just before starting romosozumab affects its therapeutic effect. Romosozumab, as an antibody targeting sclerostin, stimulates bone formation and suppresses bone resorption. The authors of the study investigated whether the efficacy of 12-month treatment with romosozumab depends on the duration of prior treatment with teriparatide, denosumab, or oral bisphosphonates.
News Protection of Ovarian Function During Breast Cancer Treatment
Women diagnosed with breast cancer of childbearing age are concerned about how to maintain ovarian function even after undergoing chemotherapy. Therefore, a team of doctors from the United Kingdom focused on the gonadotropin-releasing hormone agonist and its ability to protect women from premature menopause after chemotherapy.
News Magnetic Resonance Can Reduce the Need for Prostate Biopsies
As early as 2013, Czech experts demonstrated that in patients with elevated prostate-specific antigen (PSA) levels, imaging using a 3-Tesla magnetic resonance (3T MRI) can replace biopsy in many cases when detecting prostate cancer.
News Do Asthma Bronchiale and COPD Represent a Risk Factor for Severe COVID-19 and Death?
It is well known that patients with bronchial asthma and chronic obstructive pulmonary disease (COPD) have a higher risk of severe course of common viral respiratory diseases. A study by Belgian authors involving several hundred individuals evaluated the risk of ICU admission and death due to COVID-19 in patients with asthma and COPD compared to patients without these conditions. The other goal was to determine whether these risks are influenced by inhalation corticosteroid therapy or not.
News Current View on Prophylactic Negative Pressure Wound Therapy in Practice from Surgeons' Perspective
The journal Updates in Surgery recently published the results of a survey on prophylactic negative-pressure wound therapy (pNPWT) conducted among Swiss surgeons. The survey results show how often this therapy is used, in what situations it is typically applied, and what could make negative-pressure wound therapy more attractive in the future.
News A Brief History of Deep Vein Thrombosis Treatment – From Antiquity to the Present
Deep vein thrombosis is among the common diseases that have accompanied humanity since its inception. Due to the low specificity of its clinical presentation (in contrast to, for example, varicose veins of the lower limbs), however, the disease long went undescribed in literature. The first descriptions of deep vein thrombosis did not appear until the Middle Ages – and from that moment, the gradual development of its treatment began. We offer you a brief but remarkable historical excursion in three stages.
News Idiopathic Pulmonary Fibrosis: Rare Disease with Severe Prognosis
Idiopathic pulmonary fibrosis (IPF) represents a diagnostic and therapeutic challenge. This rare diffuse primary fibroproliferative involvement of lung tissue is characterized by progressive exertional dyspnea, with antifibrotic treatment being the first-line therapeutic modality.
News Cardiovascular Interventions with Continued Therapy with Dabigatran − Insights from the GLORIA-AF Study
An analysis using data from an international registry of patients with newly diagnosed atrial fibrillation evaluated the safety and efficacy of continued therapy with dabigatran during cardioversion or atrial fibrillation ablation, pacemaker implantation, and coronary angiography with possible stent implantation.
News MDT Board: a unique project for doctors caring for patients with lung diseases and other thoracic pathologies
A unique concept of a cooperative thoracic group has been created in the Czech Republic, involving specialists from several leading Prague clinics. The primary purpose of the so-called board is to provide the best diagnostic and treatment plan for a patient with lung disease and other pathologies in the thoracic area, shared by all members of the multidisciplinary team and based on current knowledge. The MDT Board project, which operates on the principle of online indication seminars, is intended for doctors of patients with common and rare lung diseases.