Reccurent melanoma of the vulva: case report

Czech version

Authors: Jiří Bouda ¹; Martin Pešek ¹; Václav Janda ³; Denisa Kacerovská ²; Dmitrij Kazakov ²
Authors‘ workplace: Gynekologicko-porodnická klinika LF UK a FN, Plzeň, přednosta doc. MUDr. Zdeněk Novotný, CSc. ¹; Šiklův patologický ústav LF UK a FN, Plzeň, přednosta prof. MUDr. Michal ²; Urologická klinika LF UK a FN, Plzeň, přednosta prof. MUDr. Milan Hora, Ph. D. ³
Published in: Prakt Gyn 2015; 19(1): 38-41
Category: Oncogynecology: Case report

Overview

Vulvar melanoma is the second most frequent malignant tumor of the vulva. It is usually diagnosed later and it’s prognosis is worse compared to skin melanoma. Adequate surgical procedure both at the vulva and regional lymphatic nodes is essential in early stages of vulvar melanoma whereas individual regimen with palliative intent is common in late stages.

Key words:
desmoplastic melanoma – sentinel node – vulvar melanoma

Sources

1. Shea CR, Selim MA, Robboy SJ. Vulvar cysts, neoplasms, and related lesions. In: Robboy SJ (ed) et al. Robboy’s Pathology of the Female Reproductive Tract. 2nd ed. Churchill Livingstone: London 2008: 59–94. ISBN 978–0443074776.

2. Mert I, Semaan A, Winner I et al. Vulvar/vaginal melanoma: an updated surveillance epidemiology and end results database review, comparison with cutaneous melanoma and significance of racial disparities. Int J Gynecol Cancer 2013; 23(6): 1118–1125. Dostupné z DOI: <http://dx.doi.org/10.1097/IGC.0b013e3182980ffb>. Abstract.

3. Piura B. Management of primary melanoma of the female urogenital tract. Lancet Oncol 2008; 9(10): 973–981. Dostupné z DOI: <http://dx.doi.org/10.1016/S1470–2045(08)70254–7>. Abstract.

4. Arenbergerová M, Fialová A, Pojezná E et al. Melanom vulvy. Ceska Gynekol 2013; 78(4): 351–355.

5. Krajsová I. Melanom vulvy. In: Cibula D, Petruželka L (eds). Onkogynekologie. Grada: Praha 2009: 370–380. ISBN 978–80–247–2665–6.

6. Sugiyama VE, Chan JK, Shin JY et al. Vulvar melanoma: a multivariable analysis of 644 patients. Obstet Gynecol 2007; 110(2 Pt 1): 296–301.

7. Parara S, de Bree E, Takos D, et al. Melanoma of the vulva: a pigmented lesion is also significant in a non-sun-exposed area. Arch Gynecol Obstet 2009; 280(5): 831–834. Dostupné z DOI: <http://dx.doi.org/10.1007/s00404–009–1011–6>. Abstract.

8. De Simone P, Silipo V, Buccini P et al. Vulvar melanoma: a report of 10 cases and review of the literature. Melanoma Res 2008; 18(2): 127–133. Dostupné z DOI: <http://dx.doi.org/10.1097/CMR.0b013e3282f94636>. Abstract.

9. Collina G. “Combined” desmoplastic melanoma of the vulva with poor clinical outcome. Pathologica 2011; 103(6): 337–339.

10. An J, Li B, Wu L, Lu H et al. Primary malignant amelanotic melanoma of the female genital tract: report of two cases and review of literature. Melanoma Res 2009; 19(4): 267–270. Dostupné z DOI: <http://dx.doi.org/10.1097/CMR.0b013e32831993de>. Abstract.

11. Edge SB, Byrd DR, Compton CC et al. AJCC Cancer Staging Manual. 7th ed. Springer: London. 2015. ISBN 978–1845974749.

12. Moxley KM, Fader AN, Rose PG et al. Malignant melanoma of the vulva: an extension of cutaneous melanoma? Gynecol Oncol 2011; 122(3): 612–617. Dostupné z DOI: <http://dx.doi.org/10.1016/j.ygyno.2011.04.007>. Abstract.

13. Cinotti E, Perrot JL, Labeille B et al. Reflectance confocal microscopy for the diagnosis of vulvar melanoma and melanosis: preliminary results. Dermatol Surg 2012; 38(12): 1962–1967. Dostupné z DOI: <http://dx.doi.org/10.1111/dsu.12009>. Abstract.

14. Heller DS. Pigmented vulvar lesions--a pathology review of lesions that are not melanoma. J Low Genit Tract Dis 2013; 17(3): 320–325. Dostupné z DOI: <http://dx.doi.org/10.1097/LGT.0b013e31826a38f3>. Abstract.

15. Venkatesan A. Pigmented lesions of the vulva. Dermatol Clin 2010; 28(4): 795–805. Dostupné z DOI: <http://dx.doi.org/10.1016/j.det.2010.08.007>. Abstract.

16. Trifirò G, Travaini LL, Sanvito F et al. Sentinel node detection by lymphoscintigraphy and sentinel lymph node biopsy in vulvar melanoma. Eur J Nucl Med Mol Imaging 2010; 37(4): 736–741. Dostupné z DOI: <http://dx.doi.org/10.1007/s00259–009–1358–8>. Abstract.

17. Dhar KK, DAS N, Brinkman DA et al. Utility of sentinel node biopsy in vulvar and vaginal melanoma: report of two cases and review of the literature. Int J Gynecol Cancer 2007; 17(3): 720–723.

18. Janco JM, Markovic SN, Weaver AL et al. Vulvar and vaginal melanoma: case series and review of current management options including neoadjuvant chemotherapy. Gynecol Oncol 2013; 129(3): 533–537. Dostupné z DOI: <http://dx.doi.org/10.1016/j.ygyno.2013.02.028>. Abstract.

19. Sadownik LA, Crawford RI. Post-surgical treatment of melanoma in situ of the vulva with imiquimod. J Obstet Gynaecol Can 2010; 32(8): 771–774.

20. Günther V, Alkatout I, Lez C et al. Malignant melanoma of the urethra: a rare histologic subdivision of vulvar cancer with a poor prognosis. Case Rep Obstet Gynecol 2012; 2012: 385175. Dostupné z DOI: <http://dx.doi.org/10.1155/2012/385175>.

21. Tcheung WJ, Selim MA, Herndon JE et al. Clinicopathologic study of 85 cases of melanoma of the female genitalia. J Am Acad Dermatol. 2012; 67(4): 598–605. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jaad.2011.11.921>. Abstract.