Gastric Lymphoma as a Cause of Massive Bleeding in a Patient with Castleman’s Disease

Czech version

Authors: M. Smolár; L. Šutiak ^*; A. Mikolajčík ^*; Marek Vojtko ^*; L. Plank ^**
Authors‘ workplace: Chirurgická klinika JLF UKo a MFN v Martine, Slovenská republika, prednosta: doc. MUDr. D. Mištuna. Ph. D., mim. prof. ; Chirurgická klinika JLF UKo a MFN v Martine, Slovenská republika, prednosta: doc. MUDr. D. Mištuna. PhD., mim. prof. ^*; Ústav patologickej anatómie JLF UKo a MFN v Martine, Slovenská republika, prednosta: prof. MUDr. L. Plank, CSc. ^**
Published in: Rozhl. Chir., 2010, roč. 89, č. 5, s. 320-324.
Category: Monothematic special - Original

Overview

Primary lymphomas of the stomach belong to rare gastrointestinal malignancies. In their etiology very often play role infections caused by Helicobacter pylori. Rare cause of these tumors can be systemic immunopatological disease connected with the immunodeficiency. Authors in their contribution refer about the patient with the gastric lymphoma, in which was Castleman’s disease diagnosed by the lymph-nodes biopsy. The patient was hospitalized with massive bleeding from gastric ulcers, which was treated by urgent surgical therapy. The final histological diagnosis was aggressive B-NHL of the stomach.

Key words:
primary stomach lymphoma – bleeding – Castleman’s disease

Sources

1. Marko, Ľ., Molnár, P., Koreň, R. Praktický manažment pacienta s krvácaním do tráviaceho traktu. Miniinvazívna chirurgia a endoskopia, chirurgia súčasnosti, 9, ročník, 2005, č. 2, s. 41–46.

2. Almela, P., Benages, A., Peiró, S., Anón, R., Pérez, M. M., Peňa, A., Pascual, I., Mora, F. A risk score system for identification of patients with upper – GI bleeding suitable for outpatient management. Gastrointest. Endosc., 59, 2004, č. 7, s. 772–780.

3. Šimo, J., Matis, P., Vician, M., Žiak, M. Súčasná problematika krvácania z gastroduodena. Rozhl. Chir., 2000, roč. 79, č. 7, s. 272–274.

4. Dubaj, M., Bakoš, E., Birčák, J., Galko, J., Piesecká, Ľ. Algoritmus prístupu k pacientovi s krvácaním do gastrointestinálneho traktu. Slov. Lek., 14, 2004, č. 5–6, s. 135.

5. Zavoral, M. Endoskopická léčba krvácení do trávicího ústrojí – srovnání jednotlivých technik. In.: Zavoral, M., Dítě, P., Špičák, J., Bureš, J. a kol.: Nové trendy v digestivní endoskopické diagnostice a léčbě. Grada Publishing, spol. s.r.o., Praha, 2000, 313 s.

6. Al-Akwaa, A. M., Siddiqui, N., Al-Mofleh, I. A. Primary gastric lymphoma. World J. Gastroenterol., 2004; 10(1): 5–11.

7. Mooris, A. I. Upper gastrointestinal haemorrhage – endoscopic approaches to diagnosis and treatment. In : Gilmore, I. T. and Shields, R.: Gastrointestinal Emergencies. W. B. Saunders Company, London, 1992, 392 s.

8. Parsonnet, J., Hansen, S., Rodriguez, L., Gelb, A. B., Warnke, R. A., Jellum, E., Orentreich, N., Vogelman, J. H., Friedman, G. D. Helicobacter pylori infection and gastric lymphoma. N. Engl. J. Med., 1994; 330: 1267–1271.

9. Kitamura, K., Yamaguchi, T., Okamoto, K., Ichikawa, D., Hoshima, M., Taniguchi, H., Takahashi, T. Early gastric lymphoma; a clinicopathologic study of ten patients, literature review, and compari-son with early gastric adenocarcinoma. Cancer, 1996; 77: 850–857.

10. Chandran, R. R., Raj, E. H., Chaturvedi, H. K. Primary gastrointestinal lymphoma: 30 year experience at the cancer institute, Madras, India. J. Surg. Oncol., 1995; 60: 41–49.

11. Al-Mofleh, I. A. Complications of primary upper gastrointestinal lymphoma. Ann. Saudi Med., 1992; 12: 297–299.

12. Isaacson, P. G. Recent developments in our understanding of gastric lymphomas. Am. J. Surg. Pathol., 1996; 20(Suppl 1): S1–S7.

13. Wundisch, T., Mosch, C., Neubauer, A., Stolte, M. Helicobacter pylori eradication in gastric mucosa-associated lymphoid tissue lymphoma: results of a 196-patient series. Leuk. Lymphoma, 2006; 47: 2110–2114.

14. Psyrri, A., et al. Primary extranodal lymphomas of stomach: clinical presentation, diagnostic pitfalls and management. Annals of Oncology, 19, No. 12, 2008, p. 1992–1999.

15. Yoon, S. S., et al. The diminishing role of surgery in the treatment of gastric lymphoma. Ann. Surg., 2004 Jul; 240(1): 28–37.

16. Aviles, A., Nambo, M. J., Neri, N. et al. Mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: results of a controlled clinical trial. Med. Oncol. 2005; 22: 57–62.

17. Horger, M., Bares, R., Wiefels, J., Schober, W., Mussig, K. Radiologische Befunde bei Morbus Castleman. World J. Surg. Oncol., 2005; 3; 33.

18. Greiner, T. C., Gross, T. G. Atypical immune lymphoproliferations. In: Hematology: Basic Principles and Practice. 5th ed. Hoffman R, Benz Jr. E, Shattil SJ, Furie B, Silberstein LE, McGlave P, Heslop H, eds. Philadelphia, PA. Elsevier; 2009: 1449–1459.

19. American Cancer Society: Castleman disease [on line]. [cit. 2010-1-16] Dostupné na WWW:

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