Genitourinary syndrome of menopause: hard to communicate, easy to treat
Authors:
Tomáš Fait
Authors‘ workplace:
Gynekologicko-porodnická klinika 2. LF UK a FN Motol, Praha
Published in:
Čas. Lék. čes. 2019; 158: 101-106
Category:
Review Article
Overview
About 40 % of woman suffer from vulvovaginal atrophy after menopausal transition. It is very important to put question on this problem, because about 70 % of them are not able to start discussion on it. Regarding treatment, vaginal low doses estriol and estradiol are drugs of first choice with high efficacy and safety.
Keywords:
genitourinary syndrome of menopause – vulvovaginal atrophy – vaginal application – estriol – estradiol – ospemifene – prasteron
Sources
-
Portman DJ, Gass MLS. Genitourinary syndrome of menopause. Climacteric 2014; 1: 557–556.
-
Bhatia NN, Bergman A, Karram MM. Effects of estrogen on urethral function in women with urinary incontinence. AJOG 1989; 16: 176–181.
-
Versi E, Cardozo L. Urethral vascular pulsation. Proc Int Cont Soc 198: 503–594.
-
Ulmsten U, Ekman G, Gierrz G, Malmstrom A. Different biochemical composition of connective tissue in continents and stress incontinent women. Acta Obstet Gynecol Scand 1987; 6: 147–152.
-
Rud T. The effect of estrogens and gestagens on the urethral pressure profile in urinary continent and stress incontinent women. Acta Obstet Gyn Scand 1980; 5: 265–270.
-
Fantl JA, Cardozo L, McClish DK. Estrogen therapy in the management of urinary incontinence in postmenopausal women: a meta-analysis. First report of the Hormones and Urogenital Therapy Committee. Obstet Gynecol 1994; 8: 12–18.
-
Nappi RE, Davis SR. The use of hormone therapy for the maintenance of urogynecological and sexual health post WHI. Climacteric 2012; 15: 267–274.
-
Cardozo L, Bachmann G, Mc Clish D et al. Metaanalysis of estrogen therapy in the management of urogenital atrophy in postmenopausal women. Obstet Gynecol 1998; 9: 722–727.
-
Nappi RE, Liekens G, Brandenburg U. Attitudes, perceptions and knowledges about vagina. the International Vagina Dialogue Survey. Contraception 2006; 7: 493–500.
-
Nappi RE, Kokot-Kierepa M. Women’s voices in the menopause. Results from an international survey on vaginal atrophy. Maturitas 2010; 6: 233–238.
-
Nappi RE, Kokot-Kierepa M. Vaginal Health. Insights Views & Attitudes (VIVA) – results from an international survey. Climacteric 2012; 1: 36–44.
-
Nappi RE, Mattsson LA, Lachowsky M et al. The CLOSER survey. Impact of postmenopausal vaginal discomfort on relationships between women and their partners in Northern and Southern Europe. Maturitas 2013; 75: 373–379.
-
Erekson EA, Yip SO, Wedderburn TS et al. The VSQ: a questionnaire to measure vulvovaginal symptoms in postmenopausal women. Menopause 2013; 20: 973–979.
-
Huang AJ, Gregorich SE, Kuppermann M et al. Day-to-day impact of vaginal aging questionnaire. Menopause 2014; 2: 144–154.
-
The North American Menopause Society. The 2017 hormone therapy position statement of the North American Menopause Society. Menopause 2017; 2: 728–753.
-
Cardozo L. A systematic review of estrogens for recurrent urinary tract infections. Int Urogynecol J 1999; 10(Suppl. 1), S32.
-
Rioux JE. Demlin C, Gelfand EE et al. 17beta-estradiol vaginal tablet versus conjugated equine estrogen vaginal cream to relieve menopausal atrophic vaginitis. Menopause 2000; 7: 156–161.
-
Simon J, Nachtigall L, Gut R et al. Effective treatment of vaginal atrophy with an ultra-low-dose estradiol vaginal tablet. Obstet Gynecol 2008; 112: 1053–1060.
-
Ulrich LSG, Naessen T, Elia D et al. Endometrial safety of ultra-low-dose Vagifem 10 μg in postmenopausal women with vaginal atrophy. Climacteric 2010; 1: 228–237.
-
Simon J, Nachtigall L, Ulrich LG et al. Endometrial safety of ultra-low-dose estradiol vaginal tablets. Obstet Gynecol 2010; 116: 876–883.
-
Labrie F, Martel C, Bélanger A, Pelletier G. Androgens in women are essentially made from DHEA in each peripheral tissue according to intracrinology. J Steroid Biochem Mol Biol 2017; 16: 9–18.
-
Labrie F, Derogatis L, Archer DF et al. Effect of intravaginal prasterone on sexual dysfunction in postmenopausal women with vulvovaginal atrophy. J Sex Med 2015; 12: 2401–2412.
-
DeGregorio MW, Zerbe RL, Wurz GT. Ospemifene. a first-in-class, non-hormonal selective estrogen receptor modulator approved for the treatment of dyspareunia associated with vulvar and vaginal atrophy. Steroids 2014; 9: 82–93.
-
Portman D, Palacios S, Nappi RE, Mueck AO. Ospemifene, a non-estrogen selective estrogen receptor regulator for the treatment of vaginal dryness associated with postmenopausal vulvar and vaginal atrophy. Maturitas 2014; 7: 91–98.
-
Constatine G, Graham S, Portman DJ. et al. Female sexual function improved with ospemifene in postmenopausal women with vulvar and vaginal atrophy. Climacteric 2014; 1: 1–7.
-
Bachmann GA, Komi JO. Ospemifene effectively treats vulvovaginal atrophy in postmenopausal women. Menopause 2010; 1: 480–486.
-
Portman DJ, Bachman GA, Simon JA. Ospemifene, a novel selective estrogen receptor modulator for treating dyspareunia associated with postmenopausal vulva rand vaginal atrophy. Menopause 2013; 2: 623–30.
-
Simon JA, Lin VH, Radovich C, Bachmann GA. One-year long-term safety extension study of ospemifene for the treatment of vulvar and vaginal atrophy in postmenopausal women with a uterus. Menopause 2013; 2: 418–27.
-
Behnia-Willison F, Sarraf S, Miller J et al. Safety and long-term efficacy of fractional CO2 laser treatment in women suffering from genitourinary syndrome of menopause. Eur J Obstet Gynecol Reprod Biol 2017; 21: 39–44.
-
Perino A, Cucinelle G, Gugliotta G et al. Is vaginal fractional CO2 laser treatment effective in improving overactive bladder symptoms in post-menopausal patients. Preliminary results. Eur Rev Med Pharm Sci 2016; 20; 1: 2491–2497.
-
Salvatore S, Leone RMU, Athanasiou S et al. Histological study on the effects of microablative fractional CO2 laser on atrophic vaginal tissue. an ex vivo study. Menopause 2015; 22: 845–849.
-
Siliquini GP, Tuninetti V, Bournous VE et al. Fractional CO2 laser therapy. a new challenge for vulvovaginal atrophy in postmenopausal women. Climacteric 2017;20: 379–384.
-
Eriksen B. A randomized, open, parallel group-study on the preventive effect of an estradiol-releasing vaginal ring (Estring) on recurrent urinary tract infection in postmenopausal women. Am J Obstet Gynecol 1999; 180: 1072–1079.
-
Raz R, Stamm WE. A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections. New Engl J Med 1993; 32: 753–756.
-
Kirkengen AL, Andersen P, Gjersoe E et al. Oestriol in the prophylactic treatment of recurrent urinary tract infections in postmenopausal women. Scan J Prim Health Care 1992; 1: 139–142.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
Journal of Czech Physicians
2019 Issue 3-4
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