Molecular biology and immunopathogenetic mechanisms of sepsis
Authors:
M. Průcha
Authors‘ workplace:
Nemocnice Na Homolce Praha, Oddělení klinické biochemie, hematologie a imunologie
Published in:
Čas. Lék. čes. 2009; 148: 86-90
Category:
Review Article
Overview
Sepsis, the systemic inflammatory response to infection, causes high mortality in patients in non-coronary units of intensive care. The most important characteristic of sepsis is the interaction between two subjects, the macro and the microorganism, associated with the dysfunction of innate and adaptive immunity. Sepsis is understood more as a dynamic syndrome characterized by many phenomenona which are often antagonistic. The inflammation, characterizing sepsis, does not act as a primary physiological compensatory mechanism and rather oscillates between the phase of hyperinflammatory response and anergy or immunoparalysis. The elucidation of the pathogenesis of sepsis is linked to the understanding of immunopathogenetic mechanisms, which characterize the interaction between the macro and microorganisms.
Key words:
sepsis, immunity, inflammation, apoptosis, immunogenetics.
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Journal of Czech Physicians
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