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Molecular Cytogenetics in Diagnostics of Malignant Diseases


Authors: K. Michalová;  Z. Zemanová
Authors‘ workplace: Centrum nádorové cytogenetiky, Ústav klinické biochemie a diagnostiky 1. LF UK a VFN, Praha
Published in: Čas. Lék. čes. 2006; 145: 532-537
Category: Review Article

Overview

Malignant cell transformation can be defined as series of progressive genetic events which are happening in one cell clone in limited number of specific genes. These genes could be oncogenes and/or tumor suppressor genes (antioncogenes, recessive oncogenes). Each change regardless if it is associated with initiation or progression of cancer can be related to a chromosomal rearrangement. If the aberration is above the limit of the light microscope sensitivity, it should be detected by classical cytogenetic techniques. Therefore it was hypothesized that the molecular characteristics of chromosomal rearrangements will lead to identification of genes with pivotal role in cancerogenesis. And indeed, genes important for origin of tumors were identified in recurrent chromosomal breakpoints. Until now, more than 1800 breakpoints were identified. Oncocytogenetics has remarkably developed after the introduction of molecular methods with higher sensitivity (100kb). We present a short review of molecular cytogenetic methods with a survey of specific recurrent translocations and deletions of chromosomes in several malignancies and their prognostic value is given. 

Key words:
chromosomal rearrangements, malignant tumors, leukemia, molecular cytogenetics.


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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

Article was published in

Journal of Czech Physicians


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