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An Update on Diagnostic and Prognostic Biomarkers of Early Rheumatoid Arthritis


Authors: L. Šenolt
Authors‘ workplace: Revmatologický ústav 1. LF UK, Praha
Published in: Čas. Lék. čes. 2006; 145: 538-542
Category: Review Article

Overview

Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease that leads to inevitable joint destruction. The revised American College of Rheumatology (ACR) criteria for the diagnosis of RA are not sensitive enough for classification of the very early onset of the disease. They lack the predictive value for identifying patients at high risk of rapid joint damage and for assessing the efficacy of treatment. To improve the situation, several new biomarkers are currently studied to help to achieve this goal. Respecting the pathophysilogy of RA, several markers reflecting immune response, inflammation, joint destruction, and genetic factors are discussed in this review. Finally, the potential use of several markers in the clinical practice is depicted. 

Key words:
rheumatoid arthritis, joint biomarkers, inflammation, joint destruction.


Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

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Journal of Czech Physicians


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