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Hippocampus, Structure of the Brain and Schizophrenia


Authors: T. Kašpárek;  R. Přikryl;  D. Schwarz 1;  H. Kučerová;  E. Češková
Authors‘ workplace: Psychiatrická klinika LF MU a FN, Brno ;  Centrum biostatistiky a analýz LF MU, Brno 1
Published in: Čas. Lék. čes. 2006; 145: 544-547
Category: Review Article

Overview

Schizophrenia is a clinically heterogeneous state without clearly defined pathogenesis. This limits the classification approaches with consequent lack of ability for individual treatment strategies. It becomes evident that hippocampus is a key structure in the neuropathology of schizophrenia and a concept of hippocampal reduction as an endophenotype of schizophrenia was established. The biggest support came from MRI volumetric studies. Despite that, due to some inconsistent findings, clinical consequences of hippocampal shrinkage are not yet clear. Contemporary methods of brain imaging (computation morphometry, voxel-based morphometry) could help us to outline the concept of schizophrenia and to clarify the clinical consequences of brain structure changes. 

Key words:
schizophrenia, endophenotype, morphology, volumetry, computational neuroanatomy.


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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

Article was published in

Journal of Czech Physicians


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