Taxane‑induced polyneuropathy – current possibilities of prediction and management

Czech version

Authors: Magdaléna Jablonická ¹; Lucia Žideková ²; Beata Mladosievičová ³
Authors‘ workplace: Onkologická klinika SZU, FNsP F. D. Roosevelta, Banská Bystrica ¹; Oddelenie genetiky, Medirex, a. s., Bratislava ²; Oddelenie klinickej patofyziológie, Lekárska fakulta UK, Bratislava ³
Published in: Vnitř Lék 2021; 67(1): 26-31
Category:

Overview

Peripheral neurotoxicity is the most typical non-haematological adverse effect of taxanes. Symptoms are dominated by sensory peripheral neuropathy, the incidence and degree of which depend on the cumulative dose level. The impact of neurotoxicity on the patient´s quality of life is significant, therefore it is necessary to consider the selection of therapy and the patient´s pre-existing risk factors for developing neuropathy and to get acquainted with current management options, including genetic prediction of polyneuropathy. This review article reports on a very common complication of cancer therapy that can be encountered at each internist´s outpatient dispensary.

Keywords:

paclitaxel – polyneuropathy – paresthesia – risk factors – duloxetine

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