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proLékaře.cz / Journals / Internal Medicine / 2018 - 6

Conventional and biological therapy for inflammatory bowel disease

Czech version

Authors: Martin Bortlík 1,2,3
Authors‘ workplace: Klinické a výzkumné centrum pro střevní záněty, ISCARE I. V. F. a. s., Praha 1;  Interní klinika 1. LF UK a ÚVN – Vojenské fakultní nemocnice Praha 2;  Farmakologický ústav 1. LF UK a VFN v Praze 3
Published in: Vnitř Lék 2018; 64(6): 642-653
Category: Reviews

Overview

Crohn’s disease and ulcerative colitis are chronic digestive conditions incurable by medication or surgery, which affect mainly young populations in economically developed countries. A medical treatment includes conventional preparations: aminosalicylates, corticosteroids, immunosuppressive drugs, antibiotics and exceptionally also probiotics, while in not responding patients or those at higher risk of an adverse course a biological treatment is indicated. The most frequently administered biologics are antibodies directed against the tumour-necrosis factor α, which are highly effective, but the length of their application is limited by a loss of efficiency and incidence of adverse effects. The new, more selectively acting biologics include anti-integrin antibodies and interleukin 12/23 antibodies.

Key words:

biological treatment – Crohn’s disease – idiopathic bowel inflammation – medication-based treat­ment – ulcerative colitis

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Familial adenomatous polyposis: complex patient management
The IBD outpatient care in the clinical practice
PSC-IBD: specific phenotype of inflammatory bowel disease associated with primary sclerosing cholangitis
Possibilities of therapeutic manipulation of the gut microbiota
Prokinetics and their use in gastroenterology
Colorectal cancer screening
Therapeutic digestive endoscopy I
Therapeutic digestive endoscopy II
Article was published in

Internal Medicine

Issue 6
2018 Issue 6
Most read in this issue
Topics Journals
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