Tumor angiogenesis
Authors:
Š. Lukešová 1; O. Kopecký 1; J. Dvořák 2; D. Hlávková 1; V. Vroblová 1
Authors‘ workplace:
Ústav klinické imunologie a alergologie Lékařské fakulty UK a FN Hradec Králové, přednosta MUDr. Otakar Kopecký, CSc.
1; Klinika onkologie a radioterapie Lékařské fakulty UK a FN Hradec Králové, přednosta doc. MUDr. Jiří Petera, Ph. D.
2
Published in:
Vnitř Lék 2006; 52(9): 797-800
Category:
Review
Overview
Angiogenesis have shown a major role in tumor growth and metastasis formation. For tumor growth beyond the size 1 - 2 mm3, angiogenesis must be started to form vascular supply of tumor cells. Angiogenesis is a complex process, involving degradation of the basement membrane of preexisting vessel, proliferation of endothelial cells towards the angiogenetic stimulus, maturation of endothelial cells with formation of luminized capillary, and finally formation of a functional vessel, surrounded by basement membrane and pericytes. Angiogenesis is regulated by numerous angiogenic and anti-angiogenic factors. Hypoxia is a significant stimulus for angiogenesis. For many cancers the extent of vascularisation is a negative prognostic indicator signifying aggressive disease and increased potential for metastasis.
Key words:
angiogenesis - tumor growth - metastasis - VEGF (vascular endothelial growth factor) - HIF (hypoxia inducible factor)
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Internal Medicine
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