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Platelet membrane glycoprotein IIb/IIIa in the view of its genetic changes


Authors: J. Gumulec 1;  M. Penka 2;  R. Richterová 1;  M. Brejcha 1;  D. Klodová 1;  M. Wróbel 1;  P. Janotová 1;  K. Klaricová 1;  M. Kneiflová 1;  M. Kučerová 1;  M. Radina 1
Authors‘ workplace: Centrum pro trombózu a hemostázu při Onkologickém centru J. G. Mendla, Nový Jičín, přednosta prim. MUDr. Jaromír Gumulec 1;  Oddělení klinické hematologie FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Miroslav Penka, CSc. 2
Published in: Vnitř Lék 2005; 91(7 a 8): 845-853
Category: 128th Internal Medicine Day - 21rd Vanysek's Day Brno 2005

Jako přehled bylo publikováno také formou přednášky v únoru 2004 na X. Pařízkově dni v Novém Jičíně a v listopadu 2004 na X. sympoziu MEFA v Brně

Overview

Uniqueness of the role of thrombocytes in a genesis of arterial thrombotic occlusions turns the attention to the platelets and platelet glycoproteins, which are involved in the process of platelet thrombus formation. Genetic variants of platelet glycoproteins originating from point mutations of their genes can be associated with increased thrombocyte aggregability (GP IIIa PlA1/PlA2). GP IIIa PlA2 (complex GP IIb/IIIa) variant significantly increases thrombocyte aggregability and mediates smooth muscle cells proliferation changes. Pl(A) polymorphism seems to interfere in the aetiopathogenesis of coronary disease and MI so that men with PlA2 allele have more frequently thin-walled vulnerable coronary plaques predisposed to ruptures with subsequent massive (fatal) thrombosis. On the other hand PlA1/PlA1 genotype is more frequently associated with the presence of fixed plaques when MI originates from the coronary stenosis progression. Meta-analyses of clinical trials results identify this polymorphism to be mild risk factor for coronary disease, occurrence of myocardial infarction, restenosis after percutaneous revascularisation interventions, occlusions in the site of aortocoronary bypass grafting and cerebral vascular event.

Key words:
thrombocytes – arterial thrombotic occlusions – platelet glycoproteins – glycoprotein IIb/III – coronary disease


Sources

1. Reiner AP, Kumar PN, Schwartz SM et al. Genetic variants of platelet glycoprotein receptors and risk of stroke in young women. Stroke 2000; 31: 1628–1633.

2. Benze G, Heinrich J, Schulte H et al. Association of the GPIa C807T and GPIIIa PlA1/A2 polymorphisms with premature myocardial infarction in men. Eur Heart J 2002; 34: 325–330.

3. Atherosclerosis, Thrombosis, and Vascular Biology Italian Study Group. No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age. Circulation 2003; 107: 1117–1122.

4. Weiss EJ, Bray PF, Tayback M et al. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N Engl J Med 1996; 334: 1090–1094.

5. Feng DL, Lindpaintner K, Larson MG et al. Increased platelet agregability associated with platelet GPIIIa PlA2 polymorphism: the Framingham Offspring Study. Arterioscler Thromb Vasc Biol 1999; 19:1142–1147.

6. Feng DL, Lindpaintner K, Larson MG et al. Platelet glycoprotein IIIa Pl(a) polymorphism, fibrinogen and platelet agregability: The Framingham Heart Study. Circulation 2001; 104: 140–144.

7. Carter AM, Ossei–Gerning N, Wilson IJ et al. Association of the platelet Pl(A) polymorphism of glycoprotein IIb/IIIa and the fibrinogen Bbeta 448 polymorphism with myocardial infarction and extent of coronary artery disease. Circulation 1997; 96: 1424–1431.

8. Garcia–Ribes M, Gonzales–Lamuno D, Hernandez–Estefania R et al. Polymorphism of the platelet glycoprotein IIIa in patients with coronary stenosis. Thromb Haemost 1998; 79: 1126–1129.

9. Gardemann A, Humme J, Stricker J et al. Association of the platelet glycoprotein IIIa PlA1/A2 gene polymorphism to coronary artery disease but not to nonfatal myocardial infarction in low risk patients. Thromb Haemost 1998; 80: 214–217.

10. Anderson JL, King GJ, Bair TL et al. Association between a polymorphism in the gene encoding glycoprotein IIIa and myocardial infarction or coronary artery disease. J Am Coll Cardiol 1999; 33: 727–733.

11. Ardissino D, Mannuci PM, Merlini PA et al. Prothrombotic genetic risk factors in young survivors of myocardial infarction. Blood 1999; 94: 46–51.

12. Mikkelsson J, Perola M, Laippala P et al. Glycoprotein IIIa Pl(A) polymorphism associated with progression of coronary artery disease and with myocardial infarction in autopsy series of middle–aged men who died suddenly. Arterioscler Thromb Vasc Biol 1999; 19: 2573–2578.

13. Mikkelsson J, Perola M, Kauppila LI et al: The GPIIIa Pl(A) polymorphism in the progression of abdominal aortic atherosclerosis. Atherosclerosis 1999; 147: 55–60.

14. Melus V, Pullmann R, Hybenova J et al. Is PlA1/A2 gene polymorphism of platelet membrane glycoprotein IIIa a risk factor for myocardial infarct? Bratisl Lek Listy 1999; 100: 593–597.

15. Durante–Mangoni E, Davis GJ, Ahmed N et al. Coronary thrombosis and the platelet glycoprotein IIIa gene PlA2 polymorphism. Thromb Haemost 1998; 80: 218–219.

16. Mikkelsson J, Perola M, Laippala P et al. Glycoprotein IIIa Pl (A1/A2) polymorphism and sudden cardiac death. J Am Coll Cardiol 2000; 36: 1317–1323.

17. Mikkelsson J, Perola M, Penttila A et al. The GPIIIa (™3 integrin) PlA polymorphism in the early development of coronary atherosclerosis. Atherosclerosis 2001; 154: 721–727.

18. Di Castelnuovo A, de Gaetano G, Donati MB et al. Platelet glycoprotein receptor IIIa polymorphism PlA1/PlA2 and coronary risk: a meta–analysis. Throm Haemost 2001; 85: 626–633.

19. Wu AH, Tsongalis GJ. Correlation of polymorphisms to coagulation and biochemical risk factors for cardiovascular diseases. Am J Cardiol 2001; 87: 1361–1316.

20. Goldschmidt–Clermont P, Weis E, Shear W et al. Platelets from PlA2(–) individuals bind more exogenous fibrinogen than from PlA2(+) individual. Blood 1996; 88: 26a.

21. Goodall AH, Curzen N, Panesar M et al. Increased binding of fibrinogen to glycoprotein IIIa–proline33 (HPA–1b, PlA2, Zwb) positive platelets in patients with cardiovascular disease. Eur Heart J 1999; 20: 742–747.

22. Lasne D, Krenn M, Pingault V et al. Interdonor variability of platelets response to thrombin receptor activation: influence of PlA2 polymorphism. Bj J Haematol 1997; 99: 801–807.

23. Vijayan KV, Goldschmidt–Clermont P, Ross C et al. The Pl(A2) polymorphism of integrin ™(3) enhances outside–in signaling and adhesive functions. J Clin Invest 2000; 105: 793–802.

24. Ridker PM, Hennekens CH, Schmitz C et al. PlA1/PlA2 polymorphism of platelet glycoprotein IIIa and risks of myocardial infarction, stroke and venous thrombosis. Lancet 1997; 349: 385–388.

25. Samani NJ, Lodwick D. Glycoprotein IIIa polymorphism and risk of myocardial infarction. Cardiovasc Res 1997; 33: 693–697.

26. Corral J, Gonzalez–Conejero R et al. HPA–1 genotype in arterial thrombosis: role of HPA–1b polymorphism in platelet function. Blood Coagul Fibrinlysis 1997; 8: 284–290.

27. Scaglione L, Bergerone S, Gaschino G et al. Lack of relationship between the PlA1/PlA2 polymorphism of platelet glycoprotein IIIa and premature myocardial infarction. Eur J Clin Invest 1998; 28: 385–388.

28. Mamottee CD, van Bockxmeer FM, Taylor RR. Pla1/a2 polymorphism of glycoprotein IIIa and risk of coronary artery disease and restenosis following coronary angioplasty. Am J Cardiol 1998; 82: 13–16.

29. Kekomaki S, Hamalainen L, Kauppinen–Makelin R et al. Genetic polymorphism of platelet glycoprotein IIIa with acute myocardial infarction and acute ischaemic stroke. J Cardiovasc Risk 1999; 6: 13–17.

30. Cenaro A, Casao E, Civeira F et al. P1A1/A2 polymorphism of platelet glycoprotein IIIa and risk of acute coronary syndromes in heterozygous familial hypercholesterolemia. Atherosclerosis 1999; 143: 99–104.

31. Meiklejohn DJ, Urbaniak SJ et al. Greaves M Platelet glycoprotein IIIa polymorphism HPA 1b (PlA2): no association with platelet fibrinogen binding. Br J Haematol 1999; 105: 664–666.

32. Nassar BA, Dun J, Title LM et al. Relation of genetic polymorphisms of apolipoprotein E, angiotensin–converting enzyme, apolipoprotein B–100 and glycoprotein IIIa and early–onset coronary heart disease. Clin Biochem 1999; 32: 275–282.

33. Bladbjerg EM, Andersen–Ranberg K, de Maat MP et al. Longevity is independent of common variations in genes associated with cardiovascular risk. Thromb Haemost 1999; 82: 1100–1105.

34. Bottiger C, Kastrati A, Koch W et al. HPA–1 and HPA–3 polymorphisms of the platelet fibrinogen receptor and coronary artery disease and myocardial infarction. Thromb Haemost 2000; 83: 559–562.

35. Brscic E, Bergerone S, Gagnor A et al. Acute myocardial infarction in young adults: prognostic role of angiotensin–convertin enzyme, angiotensin II type I receptor, apolipoprotein E, endotelials constitutive nitric oxide synthase and glycoprotein IIIa genetic polymorphisms et medium–term follow–up. Am Heart J 2000; 139: 979–984.

36. Aleksic N, Juneja H, Folsom AR et al. Platelet Pl(A2) allele and incidence of coronary heart disease: results from the Atherosclerosis Risk In Communities (ARIC) Study. Circulation 2000; 102: 1901–1905.

37. Herrmann SM, Poirier O, Marques–Vidal P et al. The Leu33/Pro polymorphism (PlA1/PlA2) of the glycoprotein IIIa (GPIIIa) receptor is not related to myocardial infarction in the ECTIM Study. Etude Cas–Temoins de l°Infarctus du Myocarde. Thromb Haemost 1997; 77:1179–1181.

38. Bray PF, Cannon CP, Goldschmidt–Clermont P et al. The platelet Pl (A2) and angiotensin.converting enzyme (ACE) D allele polymorphisms and the risk of recurrent events after acute myocardial infarction. Am J Cardiol 2001; 88: 347–352.

39. Barakat K, Kennon S, Hitman GA et al. Interaction between smoking and the glycoprotein IIIa Pl(A2) polymorphism in non–ST–elevation acute coronary syndrome. J Am Coll Cardiol 2001; 38: 1639–1643.

40. Rosenberg N, Zivelin A, Chetrit A et al. Effects of platelets membrane glycoprotein polymorphisms on the myocardials infarction in young males. Isr Med Assoc J 2002; 4: 411–414.

41. Rinder CS, Mathew JP, Rinder HM et al. Platelet PlA2 polymorphim and platelet activation are associated with increased troponin I release after cyrdiopulmonary bypass. Anestesiology 2002; 97: 1118–1122.

42. Gruchala M, Ciecwierz D, Ochman K et al. Association between the Pl(A) platelet glycoprotein GPIIIa polymorphism and extent of coronary artery disease. Int J Cardiol 2003; 88: 229–237.

43. Burr D, Doss H, Cooke GE et al. A meta–analysis of studies in the assotiation of the platelet PlA polymorphim of glycoprotein IIIa and risk of coronary heart disease. Stat Med 2003; 22: 1741–1760.

44. Bojesen SE, Juul K, Schnor P et al. Platelet glycoprotein IIb/IIIa Pl (A2)/Pl(A2) homozygosity associated with risk of ischemic cardiovascular disease and myocardial infarction in young men: the Copenhagen City Heart Study. J Am Coll Cardiol 2003; 42: 661–667.

45. Lagercrantz J, Bergman M, Lundman P et al. No evidence that the PlA1/PlA2 polymorphism of platelet glycoprotein IIIa is implicated in angiographically characterized coronary Atherosclerosis and premature myocardial infarction. Blood Coagul Fibrinolysis 2003; 14: 749–753.

46. Volzke H, Grimm R, Robinson DM et al. Candidate genetic markers and the risk of restenosis after coronary angioplasty. Clin Sci (Lond) 2004; 106: 35–42.

47. Boekholdt SM, Peters RJ, de Maat MP et al. Interaction between a genetic variant of the platelet fibrinogen receptor and fibrinogen levels in determining the risk of cardiovascular events. Am Heart J 2004; 147: 181–186.

48. Walter DH, Schachinger V, Elsner M et al. Platelet glycoprotein IIIa polymorphisms and risk of coronary stent thrombosis. Lancet 1997; 350: 1217–1219.

49. Laule M, Cascorbi I, Stangl V et al. A1/A2 polymorphism of glycoprotein IIIa and association with excess procedural risk for coronary catheter interventions: a case–controled study. Lancet 1999; 353: 708–712.

50. Kastrati A, Schomig A, Seyfarth M et al. PlA polymorphism of platelet glycoprotein IIIa and risk of restenosis after coronary stent placement. Circulation 1999; 99: 1005–1010.

51. Zotz RB, Klein M, Dauben HP et al. Prospective analysis after coronary–artery bypass grafting: platelet GP IIIa polymorphism (HPA–1b/PlA2) is a risk factor for bypass occlusion, myocardial infarction and death. Thromb Haemost 2000; 83: 404–407.

52. Kastrati A, Koch W, Gawaz M et al. PlA polymorphism of glycoprotein IIIa and risk of adverse events after coronary stent placement. J Am Coll Cardiol 2000; 36: 84–89.

53. Walter DH, Schachinger V, Elsner M et al. Statin therapy is associated with reduced restenosis rates after coronary stent implantation in carriers of the Pl (A2) allele of the platelet glycoprotein IIIa gene. Eur Heart J 2001; 22: 587–595.

54. Gorchakova O, Koch W, Mehilli J et al. Pl (A) polymorphism of the glycoprotein IIIa and efficacy of reperfusion therapy in patients with acute myocardial infarction. Thromb Haemost 2004; 91: 141–145.

55. Wagner KR, Giles WH, Johnson CJ et al. Platelet glycoprotein receptor IIIa polymorphim PlA2 and ischemic stroke risk: the Stroke Prevention in Young Women Study. Stroke 1998; 29: 581–585.

56. Carter AM, Catto AJ, Bamford JM et al. Platelet GP IIIa PlA and GP Ib variable number tandem repeat polymorphism and markers of platelet activation in acute stroke. Arterioscler Thromb Vasc Biol 1998; 18: 1124–1131.

57. Carlsson LE, Greinacher A, Spitzer C et al. Polymorphisms of the human platelet antigens HPA–1, HPA–2, HPA–3 and HPA–5 on platelet receptors for fibrinogen (GPIIa/IIIa), von Willebrand factor (GPIb/IX) and collagen (GPIa/IIa) are not correlated with an increased risk for stroke. Stroke 1997; 28: 1392–1395.

58. Pongracz E, Tordai A, Csornai M et al. Platelet glycoprotein IIa/IIIa (LeuPro33) polymorphism in stroke patients. Orv Hetil 2001; 142: 781–785.

59. Pongracz E, Tordai A, Csornai M et al. Genetics of blood coagulation in young stroke patients. Ideggyogy Sz 2002; 55: 111–117.

60. van Goor ML, Gomez Garcia E, Brouwers GJ et al. Pl A1(A2 polymorphism of the platelet glycoprotein receptor IIb/IIIa in young patients with cryptogenic TIA or ischemic stroke. Thromb Res 2002; 108: 63–65.

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