A rare complication after aortocoronary bypass: acute cholestatic hepatitis and agranulocytosis induced by ticlopidin and simvastatin in patients allergic to salicilates

Czech version

Authors: J. Málková ¹; I. Hoffmanová ²; J. Knot ¹; J. Votava ³
Authors‘ workplace: III. interní - kardiologická klinika 3. lékařské fakulty UK a FN Královské Vinohrady, Praha, přednosta prof. MUDr. Petr Widimský, DrSc., FESC ¹; II. interní klinika 3. lékařské fakulty UK a FN Královské Vinohrady, Praha, přednosta prof. MUDr. Michal Anděl, CSc. ²; Kardiochirurgická klinika 3. lékařské fakulty UK a FN Královské Vinohrady, Praha, přednosta prof. MUDr. Zbyněk Straka, CSc. ³
Published in: Vnitř Lék 2005; 51(11): 1303-1305
Category: The case

Předneseno na semináři Kardiocentra 3. LF UK a FN Královské Vinohrady v Praze v roce 2004.

Overview

Unusual case of acute cholestatic hepatitis and agranulocytosis associated with the use of antiplatelet agent ticlopidine and simvastatine in patient with ASA intolerance after CABG is reported.

Keywords:
ticlopidine – simvastatin – aortocoronary – bypass – clopidogrel – agranulocytosis – cholestatic hepatitis

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