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Elevated lipoprotein-associated phospholipase A2 in geriatric patients


Authors: MUDr. Jo O Fortunato 1;  MUDr. Michaela Fortunato 1;  prof. MUDr. Vladimír Blaha, CSc. 1;  MUDr. Josef Bis, Ph.D. 2;  doc. RNDr. Ctirad Andrýs, Ph.D. 3;  MUDr. Božena Jurašková, Ph.D. 1;  prof. MUDr. Luboš Sobotka, CSc. 1
Authors‘ workplace: III. interní gerontometabolická klinika, FN Hradec Králové 1;  I. interní karioangiologická klinika, FN Hradec Králové 2;  Ústav klinické imunologie a alergologie, FN Hradec Králové 3
Published in: Geriatrie a Gerontologie 2020, 9, č. 2: 97-100
Category: Original Article

Overview

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is extensively expressed by advanced atherosclerotic lesions and may play a role in plaque instability. We selected a group of elderly subjects that underwent transcatheter aortic valve implantation (TAVI) or balloon angioplasty (BA) and separated them into two groups, diabetic and nondiabetic, to compare the level of Lp-PLA2 mass between them.

Methods: 44 patients aged 79.6 ± 5.6 years with symptomatic severe aortic valve stenosis underwent TAVI (n = 35) or BA (n = 9). 21 subjects had confirmed type 2 diabetes mellitus. Lp-PLA2 mass was measured using an enzyme- linked immunosorbent assay kit (USCN Life Science, China) before and 3 days after the procedure.

Results: Lp-PLA2 mass was significantly elevated in this population (1296 ± 358 ng/mL before TAVI; 1413 ± 268 ng/mL before BA) and further increased after TAVI (1604 ± 437 ng/mL, P < 0.01) or BA (1808 ± 303 ng/mL, P < 0.01). Lp-PLA2 mass was significantly increased on the diabetic group before these interventions.

Conclusion: Lp-PLA2 may be a novel biomarker for the presence of rupture-prone atherosclerotic lesions in elderly patients. Levels of Lp-PLA2 in diabetic patients may accompany the higher amount of small dense LDL particles seen in these subjects.

Keywords:

Atherosclerosis – diabetes mellitus – transcatheter implantation – Aortic valve – aortic stenosis – balloon angioplasty – Lipoprotein associated phospholipase


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