Coronavirus infection within senior people – The immunologist’s view

Czech version

Authors: doc. MUDr. Pavlína Králíčková, Ph.D.
Authors‘ workplace: Ústav klinické imunologie a alergologie, FN Hradec Králové
Published in: Geriatrie a Gerontologie 2020, 9, č. 2: 61-65
Category: Review Article

Overview

Virus SARS-CoV-2 is a cause pathogen of covid-19 disease. The age represents an independent risk factor for prognosis. A key role play immunosenescence and cumulating comorbidities. In relation to covid-19 infection should be highlighted factors such as weakening of mucosal barrier, decreased response to Toll-like receptors stimulation, NK cells decline with limited interferon gamma production, deterioration of specific immunity to new antigenic challenge and leaning towards more intensive proinflammatory response.

Keywords:

COVID-19 – immunosenescence –  aging – ACE2

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