Early cancerogenesis in head and neck squamous cell carcinoma
Authors:
J. Kastner 1; J. Bouček 1,2; J. Betka 1,2; J. Plzák 1,3,4; M. Jáchymová 5; J. Betka 1
Authors‘ workplace:
Klinika otorhinolaryngologie a chirurgie hlavy a krku 1. LF UK a FN v Motole, Katedra otorhinolaryngologie IPVZ, Praha
Přednosta: Prof. MUDr. Jan Betka, DrSc.
1; Mikrobiologický ústav AV ČR, Sektor Imunologie a gnotobiologie, Praha
Vedoucí: Prof. RNDr. Blanka Říhová, DrSc.
2; Anatomický ústav 1. LF UK, Praha
Přednosta: Prof. MUDr. Miloš Grim, DrSc.
3; Centrum buněčné terapie a tkáňových náhrad 2. LF UK, Praha
Vedoucí: Prof. MUDr. Eva Syková, DrSc.
4; Ústav klinické biochemie a laboratorní diagnostiky 1. LF UK a VFN, Praha
Přednosta: Prof. MUDr. Tomáš Zima, DrSc., MBA.
5
Published in:
Prakt. Lék. 2008; 88(9): 501-505
Category:
Reviews
Overview
Squamous cell carcinoma is the most frequent malignant tumour of the head and neck. It affects more than one thousand patients in the Czech Republic each year. Despite advances in surgical techniques (endoscopic surgery, functional neck dissection etc.), instruments (laser, harmonic ultrascission knife, radiofrequency a.o.) and oncology guidelines, the overall 5-year survival rate remains under 50 %. The article reviews current data on early cancerogenesis of head and neck squamous cell carcinoma and outlines possible research trends.
Key words:
head and neck squamous cell carcinoma, tailored medicine, molecular biology, field cancerization, biochip, RT-PCR.
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2008 Issue 9
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