Helicobacter pylori and gastric cancer
Authors:
Š. Suchánek 1,2; I. Kuzko 1; K. Košťálová- 1 3; Z. Vacková 1; P. Urbánek 1; M. Zavoral 1,2; J. Bureš 1,2
Authors‘ workplace:
Interní klinika 1. LF UK a ÚVN Praha
1; Ústav gastrointestinální onkologie 1. LF UK a ÚVN Praha
2; Katedra vojenského vnitřního lékařství VLF OU, Hradec Králové
3
Published in:
Gastroent Hepatol 2024; 78(5): 395-401
Category:
doi:
https://doi.org/10.48095/ccgh2024395
Overview
Helicobacter pylori belongs to the most common bacterial infections worldwide; despite its decreasing prevalence during the past four decades (currently ~ 40–50%), it is more prevalent in developing countries compared to developed ones. Intensive research of chronic Helicobacter pylori infection clarified the pathogenesis of several gastric and extragastric diseases, including different cancers. This review pointed out the role of Helicobacter pylori in different gastric malignancies. Chronic Helicobacter pylori infection is an etiological factor in non--cardia gastric cancer and most cases of low-grade MALT lymphoma of the stomach. However, there is an inverse association of Helicobacter pylori infection with other gastric malignancies, like cardia gastric cancer or rare hereditary Gastric Adenocarcinoma and Proximal Polyposis of the Stomach syndrome (GAPPS). A crucial issue has not been definitely solved yet: whether early eradication of Helicobacter pylori could prevent sporadic gastric cancer in the future? There is moderate evidence that searching for and eradicating Helicobacter pylori reduces the incidence of gastric cancer and death from gastric cancer in healthy asymptomatic infected Asian individuals, although data cannot necessarily be extrapolated to European or US populations so far. Indication for the eradication of Helicobacter pylori must now be considered with caution, on an individual basis of personalized medicine.
Keywords:
gastric cancer – gastrointestinal oncology – Helicobacter pylori – Helicobacter spp. – MALT-lymphoma – microbiome
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ORCID autorů
Š. Suchánek 0000-0003-3659-0252,
I. Kuzko 0009-0003-2638-6378,
K. Košťálová 0000-0003-2505-9239,
Z. Vacková 0000-0002-0443-5752,
P. Urbánek 0000-0002-1506-1135,
M. Zavoral 0000-0001-7883-7431,
J. Bureš 0000-0003-0326-117X.
Doručeno/Submitted: 7. 10. 2024
Přijato/Accepted: 15. 10. 2024
Korespondenční autor
doc. MUDr. Štěpán Suchánek, Ph.D.
Interní klinika
1. LF UK a ÚVN Praha
U Vojenské nemocnice 1200
169 02 Praha 6
stepan.suchanek@uvn.cz
Labels
Paediatric gastroenterology Gastroenterology and hepatology SurgeryArticle was published in
Gastroenterology and Hepatology
2024 Issue 5
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