Has everything really been discovered about SGLT2 inhibitors?

Czech version

Authors: Daša Skripová
Authors‘ workplace: Diabetologická ambulancia ARETEUS s. r. o., Trebišov
Published in: Diab Obez 2019; 19(38): 98-102
Category: Reviews

Výsledky veľkých randomizovaných klinických štúdií s novými skupinami antidiabetík (DPP4-inhibitórmi, GLP1 RA, gliflozínmi) zásadne ovplyvnili názory na liečbu a smerovanie súčasnej diabetológie. Okrem toho, čo si tieto klinické štúdie kládli primárne za úlohu, t.j. dokázať kardiovaskulárnu bezpečnosť nového antidiabetika, sa ukázalo, že niektoré majú kardioprotektívne účinky. Ovplyvnenie viacerých kardiometabolických rizikových faktorov aterosklerózy sa u diabetikov považuje za veľmi žiaduce, keďže veľká väčšina diabetikov 2 typu zomiera na kardiovaskulárne ochorenia.

Overview

The results of large randomized clinical trials with new classes of antidiabetic agents – ADAs (DPP4 inhibitors, GLP1RA, gliflozins), have fundamentally influenced the views on the management of type 2 diabetes mellitus. Besides the primary endpoint of these trials (to prove cardiovascular safety of each new ADA), some of ADAs in these trials have shown cardioprotective effects. Majority of type 2 diabetics die of cardiovascular disease (CVD), so influencing multiple cardiometabolic risk factors of atherosclerosis is highly desirable. In addition, some ADAs in cardiovascular outcome trials shown to have a renoprotective effect too, and to some extent delayed the onset and progression of chronic kidney disease (CKD).

Keywords:

cardioprotective effect – empagliflozin – EMPA-REG-OUTCOME Study – renoprotective effect – SGLT2

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