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Composite follicular lymphoma and in situ mantle cell neoplasia of lymph node: identification based on flow cytometry investigation

Czech version

Authors: Tomáš Jirásek 1;  Marcela Mrhalová 2;  Tomáš Zajíc 3;  Miroslav Genský 4;  Tomáš Klinger 1;  Vít Campr 2
Authors‘ workplace: Oddělení patologie, Centrum PATOS, Krajská nemocnice Liberec, a. s. 1;  Ústav patologie a molekulární medicíny 2. LF UK a Fakultní nemocnice v Motole, Praha 2;  Oddělení molekulární genetiky a diagnostiky, Centrum PATOS, Krajská nemocnice Liberec, a. s. 3;  Oddělení klinické hematologie, Centrum laboratorní medicíny, Krajská nemocnice Liberec, a. s. 4
Published in: Čes.-slov. Patol., 59, 2023, No. 4, p. 177-183
Category: Original Article

Overview

The aim of the presented case report is to acquaint the wider professional public with a rare case of composite follicular lymphoma (FL) and in situ mantle cell neoplasia (ISMCN) in a lymph node. In both components, characteristics of tumor cells populations were investigated primarily using flow cytometry. The patient was diagnosed with a combination of composite FL grade 3A (FL-G3A) and ISMCN, this finding was also confirmed by histopathological and immunohistochemical examination of the lymph node and complemented by fluorescence in-situ hybridization (FISH). The described case shows the diagnostic difficulties in detecting this rare lesion and an important role of flow cytometry in diagnostics of lymphomas.

Keywords:

Flow cytometry – follicular lymphoma – Composite lymphoma – In-situ mantle cell neoplasia

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