Mantle cell lymphoma diagnosed from radical prostatectomy for prostate adenocarcinoma: a case report

Czech version

Authors: Eliška Tvrdíková ¹; Leoš Křen ¹; Alena Sorokač Kubolková ²; Dalibor Pacík ²
Authors‘ workplace: Ústav patologie, FN Brno, Lékařská fakulta, Masarykova univerzita, Brno ¹; Urologická klinika, FN Brno, Lékařská fakulta, Masarykova univerzita, Brno ²
Published in: Čes.-slov. Patol., 55, 2019, No. 4, p. 231-234
Category: Original Articles

Overview

We present a case of 64 – year – old man with mantle cell lymphoma (MCL) diagnosed in radical prostatectomy for adenocarcinoma. Lymphoma of the prostate, either primary or secondary, is a rare entity. The prognosis of lymphoma involving the prostate is usually poor. The most common form of leukemia/lymphoma involving the prostate is that of chronic lymphocytic leukemia/lymphoma (CLL/SLL). Mantle cell lymphoma of the prostate is an exceedingly rare entity. The association between MCL and urologic cancer was previously described, however the etiologic connection between these two conditions remains unknown. The pathologists should pay attention to all lymphoid infiltrates in the prostate, especially in cases when these are dense.

Keywords:

Adenocarcinoma – duplicity – mantle cell lymphoma – prostate

Sources

1. Bostwick DG, Cheng L. Urologic surgical pathology (3rd ed). Elsevier Saunders; 2014: 528-530.

2. Epstein JI, Netto GJ. Biopsy interpretation of the prostate (5th ed). Wolters Kluwer; 2015: 368-370.

3. Smedby KE, Hjalgrim H. Epidemiology and etiology of mantle cell lymphoma and other non-Hodgkin lymphoma subtypes. Semin Cancer Biol 2011; 21(5): 293-298.

4. Ventura RA, Martin-Subero JI, Jones M, et al. FISH analysis for the detection of lymphoma-associated chromosomal abnormalities in routine paraffin-embedded eissue. J Mol Diagn 2006; 8(2): 141-151.

5. Mills SE, Greenson JK, Hornick JL, Longacre TA, Reuter VE. Sternberg´s Diagnostic Surgical Pathology, Volume II (6th ed.). Wolters Kluwer; 2015: 2133.

6. Bostwick DG, Iczkowski KA, Amin MB, Discigil G, Osborne B. Malignant lymphoma involving the prostate: report of 62 cases. Cancer 1999; 83(4): 732-738.

7. Abdussalam A, Gerridzen RG. Mantle cell lymphoma of the prostate. Can Urol Assoc J 2009; 3(6): E94-E95.

8. Chen B, Yin G, Duan L, Li W, Jiang X. A new marker, SOX11, aids the diagnosis of mantle cell lymphoma in the prostate: A case report. Oncol Lett 2012; 4(2): 265-267.

9. Rajput AB, Burns B, Gerridzen R, van der Jagt R. Coexisting mantle cell lymphoma and prostate adenocarcinoma. Case Rep Med 2014: 247286.

10. Petković I, Stojnev S, Krstić M, Pejčić I, Vrbić S. Synchronous mantle cell lymphoma and prostate adenocarcinoma – is it just a coincidence?. Vojnosanit Pregl. 2016; 73(11): 1072-1075.

11. Mills SE, Greenson JK, Hornick JL, Longacre TA, Reuter VE, eds. Sternberg´s Diagnostic Surgical Pathology, Volume I (6th ed.). Wolters Kluwer; 2015: 707.

12. Taleb A, Ismaili N, Belbaraka R, et al. Primary lymphoma of the prostate treated with rituximab – based chemotherapy: a case report and review of the literature. Cases J 2009; 2: 8875.

13. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC; 2017: 289.