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Expression of P53, P21 and bcl-2 in Prognostic Lung Carcinomas


Authors: N. V. Nhung;  T. Miřejovský;  P. †miřejovský;  L. Melínová *
Authors‘ workplace: Hlavův I. patologickoanatomický ústav 1. LF UK a VFN Praha, přednosta †prof. MUDr. P. Miřejovský, DrSc. Pneumologická klinika 1. LF UK, Praha - Veleslavín, přednosta doc. MUDr. B. Šťastný, CSc.
Published in: Čes.-slov. Patol., , 1999, No. 4, p. 117-121
Category:

Overview

Expression of suppressor genes 53 and bcl-2 as well as of protein p21 (partly induced by p53 gene)was analyzed in a group of 77 resection specimens and bronchial excision of lung carcinomas (ofall basic histological types - squamous cell, neuroendocrine, adenocarcinoma, undifferentiated).Simultaneously the relation of tumor immunophenotype and level of differentiation, cell deathand 2-year-survival of patients was evaluated.Gene p53 showed non-only an expected strong expression in squamous cell carcinomas but espe-cially in adenocarcinomas, which were newly characterized by exceptional hyperexpression ofp53 in lowly differentiated variants.Expression level of protein p21 and gene p53 was parallel only in adenocarcinomas and undiffe-rentiated carcinomas but discordant in squamous cell and neuroendocrine carcinomas. Positivityof p21 slightly prevailed in well-differentiated variants of the histological types but an exceptio-nal positivity was found even in all the undifferentiated carcinomas.Gene bcl-2 revealed a paradox of strong expression in lowly differentiated neuroendocrine andundifferentiated carcinomas. The level of bcl-2 expression in squamous cell carcinomas was foundhigher than in references. Among tumors with cell death there was an inverted relation of bcl-2and p53 expression (high/low) in neuroendocrine carcinomas but both of them were mostly nega-tive in squamous cell carcinomas.A more frequent 2-year-surival of squamous cell carcinomas was verified for bcl-2 positive tumorsand newly for p53 positive squamous cell carcinomas.Evaluation of the expression of p53, p21 and bcl-2 in lung carcinomas is so equivocal that itsprognostic usage was found to be only complementary to the direct immunohistochemical investi-gation of the growth activities.

Key words:
lung carcinoma - immunophenotypical expression - p53-p21-bcl-2 Differentiation levelof tumor - tumors with cell death - survival

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