#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

TREATMENT OF PROSTATE CANCER IN THE CZECH REPUBLIC IN 2016: OUTCOMES OF WORKSHOPS ON METASTATIC CASTRATION-RESISTANT PROSTATE CANCER (MCRPC)


Authors: Michaela Matoušková 1,4,5;  Marko Babjuk 2,4;  Jan Krhut 3,4;  Veronika Črepová 4
Authors‘ workplace: Urocentrum Praha 1;  Urologická klinika 2. LF a FN Motol, Praha 2;  Urologické oddělení FN Ostrava 3;  Česká akademie urologie, Česká urologická společnost ČLS JEP 4;  Onkologická klinika FTN a 1. LF UK, Praha 5
Published in: Ces Urol 2017; 21(1): 85-95
Category: Information

Overview

During spring 2016, thirteen workshops on metastatic castration-resistant prostate cancer (mCRPC) were held in larger towns in the Czech Republic, attended by a large group of urologists and oncologists. All the workshops followed a similar scenario, with an initial communication about mCRPC and case report discussion along with seeking consensus in a group of urologists and oncologists divided into teams led by local specialists (a urologist and an oncologist), and a comparison of outcomes of both groups. Consensus outcomes of the workshops are presented in this article.

KEY WORDS:
Malignant prostate cancer, hormone-sensitive prostate cancer, metastatic castration-resistant prostate cancer.


Sources

1. Mottet N, Bellmunt J, Briers E, et al. Guidelines on prostate cancer EAU 2017 © Copyright 2017 Uroweb http://uroweb.org/guideline/prostate‑cancer/.

2. Tannock IF, de Witt R, Berry WR, et al. Docetaxel plus prednisone or Mitoxantrone plus prednisone for advanced prostate cancer. New Engl J Med 2004; 351: 1502–1512.

3. De Bono JS, Oudard S, Ozguroglu M, et al. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration‑resistant

prostate cancer progressing after docetaxel treatment: a randomised open‑label trial. Lancet 2010; 376: 1147–1154.

4. Fizazi K, Scher HI, Molina A, et al. Abiraterone acetate for treatment of metastatic castration‑resistant

prostate cancer: final overall survival analysis of the COU‑AA-301 randomised, double‑blind, placebo‑controlled phase 3 study Lancet 2012; 13(10): 983–992.

5. Scher HI, Fizzazi K, Saad F, et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. NEJM 2012; 367(13): 1187–1197.

6. Ryan CJ, Smith MR, Fizazi, et al. Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy‑naive men with metastatic castration‑resistant prostate cancer (COU‑AA-302): final overall survival analysis of a randomised, double‑blind, placebo‑controlled phase 3 study. Lancet 2015; 16(2): 152–160.

7. Beer TM, Armstrong AJ, Rathkopf DE, et al. Enzalutamide in Metastatic Prostate Cancer before Chemotherapy. N Engl J Med 2014; 371: 424–433.

8. Kantoff PW, Gitano CS, Shore ND, et al. Sipuleucel‑T Immunotherapy for Castration‑Resistant Prostate Cancor. N Engl J Med 2010; 363: 411–422.

9. Fizazi K, Carducci M, Smith M, et al. Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double‑blind study. Lancet 2011; 377: 813–822.

10. Parker C, Nilsson S, Heinrich D, et al. Alpha Emitter radium-223 and Survival in Metastatic prostate Cancer.N Engl J Med 2013; 369: 213–223.

11. James ND, Spears MR, Clarke NW, et al. Survival with Newly Diagnosed Metastatic Prostate Cancer in the ‘‘Docetaxel Era’’: Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019). Eur Urol 2015; 67: 1028–1038.

12. Sweney MB, Yu‑Hui BS, Carducci M, el al. Chemohormonal Therapy in Metastatic Hormone‑Sensitive Prostate Cancer. N Engl J Med 2015; 373: 737–746.

13. Ferlay J, Parkin DM, Steliarova‑Foucher E. Estimates of cancer incidence and mortality in Europe in 2008 € J Cancer, 2010; 46(4): 765–781.

14. Berthold DR, Pond GR, Roessner M, et al. TAX-327 investigators. Treatment of hormone‑refractory prostate cancer with docetaxel or mitoxantrone: relationships between prostate‑specific antigen, pain, and quality of life response and survival in the TAX-327 study. Clinical Cancer Research 2008; 14: 2763–2767.

15. Parker C, Nilsson S, Heinrich D, et al. Alpha Emitter radium-223 and Survival in Metastatic prostate Cancer.N Engl J Med 2013; 369: 213–223.

16. Newling DW, Fossa SD, Tunn UW, el al. Mitomycin C versus estramustine in the treatment of hormone resistant metastatic prostate cancer: the final analysis of the European Organization for Research and Treatment of Cancer, genitourinary group prospective randomized phase III study (30865). J Urol. 1993 Dec; 150(6): 1840–1844.

17. Mohan R, Panda D. Kinetic Stabilization of Microtubule Dynamics by Estramustine Is Associated with Tubulin Acetylation, Spindle Abnormalities, and Mitotic Arrest. Cancer Res 2008; 68: 6181–6189. Published online August 1, 2008.

Labels
Paediatric urologist Nephrology Urology
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#