Optimization of Combined Treatment of Retinoblastoma

Czech version

Authors: P. Pochop ¹; J. Mališ ²; J. Řehůřek ³; B. Šímová ²; G. Šimonová ⁴
Authors‘ workplace: Oční klinika dětí a dospělých, 2. LF UK a FN Motol, Praha, přednostka doc. MUDr. D. Dotřelová, CSc. 2Klinika dětské onkologie 2. LF UK a FN Motol, Praha, přednosta prof. MUDr. J. Koutecký, DrSc. 3Dětská oční klinika, DFN Brno, přednosta prof. MUDr. J. Řeh ¹
Published in: Čes. a slov. Oftal., , 2004, No. 2, p. 105-111
Category:

Overview

Eighteen patients suffering of retinoblastoma during three years period (1999-2001) were treated in two departments of ophthalmology in the Czech Republic.In four cases, the involvement was bilateral. In six eyes, because of very late stageof the disease at the time of diagnosis, the initial treatment was the enucleation.The rest, (sixteen eyes) was treated by chemoreduction (chemotherapy) anddifferent combinations of local therapeutic methods according to their respectivefindings. Nine eyes from this cohort were enucleated in different period of timeafter the beginning of the treatment because of the relapse of the disease, itscontinuing or complications of the treatment. In the remaining seven eyes thereare no sings of tumor activity. The fractioned radiotherapy was used in thetreatment in one eye only and this eye was enucleated subsequently. So themaintaining therapy was successful in seven eyes of sixteen involved, or in 43.75%of cases.

Key words:
retinoblastoma,chemoreduction(chemotherapy), transpupillary thermotherapy,radiotherapy, tumors of the eye

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