Brief analysis of the frequency of use and spectrum of animal models in stroke research

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Authors: J. Hložková ^1,2; V. Juračková ²; P. Suchý Jr. ²; P. Scheer ^1,2; R. Mikulík ¹
Published in: Cesk Slov Neurol N 2019; 82(3): 274-278
Category: Review Article
doi: https://doi.org/10.14735/amcsnn2019274

Overview

Aim: The development of new drugs and curative treatments without animal models is currently not possible. Due to the unique complexity of stroke, the number of models studying this is unusually extensive. The aim of the overview is to describe and simply analyse used experimental models and commonly used animal species in research in vascular events.

Methods: The publications were searched in November 2017 in databases: PubMed, Science Direct, Wiley Online Library and Springer Link by using key word combinations. There was the registered type of model, species of animal, its gender and age of the animal for each stroke model, and there was the registered frequency of occurrence in monitored publication databases. Relevant publications and duplications were not excluded.

Results: There were 3,093 relevant links from 26,198 articles, which correspond to the specification of the methodology. The results were processed in an overviewed table.

Conclusion: The article maps the frequency of use of animal models and used animal species in the field of stroke.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Keywords:

rat – pig – animal stroke model – mouse – rabbit – sheep – gerbil – cat – dog – non-human primates

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