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Monocyte distribution width and its application for early diagnosis of sepsis


Authors: P. Lehnert;  M. Šrámková;  R. Průša
Authors‘ workplace: Ústav lékařské chemie a klinické biochemie, 2. Lékařská fakulta Univerzity Karlovy a FN Motol, V Úvalu 84, Praha 5, 150 06
Published in: Klin. Biochem. Metab., 30, 2022, No. 1, p. 5-11

Overview

Sepsis is the leading cause of death from infectious diseases. This is one of the most common causes of death. Time is a key factor in starting treatment early, and therefore recognizing patients with a high risk of development of sepsis who are not recognized as critical at the time of admission. In addition to the established biomarkers such as C-reactive protein or procalcitonin, new biomarkers are emerging that reflect their cell in the immune response. One of these biomarkers is Monocytic Distribution Width (MDW). Three subpopulations of monocytes and dendritic cells were characterized in peripheral blood. During sepsis, functional reprogramming occurs between monocytes and macrophages, which causes not only morphological changes but also changes in cell volume. These changes are reflected in the so-called monocytic distribution width, which can be a potential biomarker, or a complementary biomarker, for early diagnosis of sepsis at emergency departments. This is a parameter routinely determined with a differential leukocyte count. According to the recent literature, a suitable MDW cut-off value for sepsis is approximately 23.0 for samples with K3EDTA (respectively 20.5 for K2EDTA).

Keywords:

Monocytes – sepsis – monocytic distribution width


Sources

1. Singer, M., Deutschman, C. S., Seymour, C. W., et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3), JAMA, 2016, 315, s. 801-810.

2. Matějovič, M. Sepse a její nová definice, Postgraduální nefrologie, 2017, 15(1), s. 4-8.

3. Goto, T., Yoshida, K., Tsugawa, Y., et al. Infection Disease-Related Emergency Department Visits of Elderly Adults in the United States, 2011-2012. J. Am. Geriatr. Soc., 2016, 64, s. 31-36.

4. Fleischmann, C., Scherag, A., Adhikari, N. K., Hartog, C. S., Tsaganos, T., Schlattmann, P., et al. International Forum of Acute Care Trialists Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations, Am. J Respir. Crit. Care Med., 2016, 193(3), s. 259-272.

5. Sinha, M., Jupe, J., Mack, H., Coleman, T. P., Lawrence, S. M., Fraley, S. I. Emerging Technologies for Molecular Diagnosis of Sepsis. Clin. Microbiol. Rev., 2018, 31(2), e00089-17.

6. Heper, Y., Akalin, E. H., Mistik, R., Akgöz, S., Töre, O., Göral, G., et al. Evaluation of serum C-reactive protein, procalcitonin, tumor necrosis factor alpha, and interleukin-10 levels as diagnostic and prognostic parameters in patients with community-acquired sepsis, severe sepsis, and septic shock. Eur. J Clin. Microbiol. Infect. Dis., 2006, 25(8), s. 481-491.

7. Ruan, Q., Yang, K., Wang, W., Jiang, L., Song, J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intens. Care Med., 2020, 46(5), s. 846–848.

8. Chen G, Wu, D., Guo, W., et al. Clinical and immunologic features in severe and moderate Coronavirus Disease 2019. J Clin. Invest., 2020, 130(5), s. 2620-2629.

9. Laguna-Goya, R., Utrero-Rico, A., Talayero, P., Lasa-Lazaro, M., Ramirez-Fernandez, A., Naranjo, L., et al. IL-6-based mortality risk model for hospitalized patients with COVID-19. J Allergy Clin. Immunol., 2020, 146(4), s. 799-807.

10. Copaescu, A., Smibert, O., Gibson, A., Phillips, E. J., Trubiano, J. A. The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection. J Allergy Clin. Immunol., 2020, 146(3), s. 518– 534.

11. Piccioni, A., Santoro, M. C., de Cunzo, T., et al. Presepsin as Early Marker of Sepsis in Emergency Department: A Narrative Review. Medicina (Kaunas), 2021, 57(8), s. 770-781.

12. Fajgenbaum, D. C., and June, C. H. Cytokine Storm. N Engl. J Med., 2020, 383(23), s. 2255-2273.

13. van der Geest, P. J., Mohseni, M., Linssen, J., Duran, S., de Jonge, R., Groeneveld, A. B. The intensive care infection score - a novel marker for the prediction of infection and its severity. Crit. Care, 2016, 20(1), s. 180-188.

14. Sukhacheva, E. The Role of Monocytes in the Progression of Sepsis. Clin. Lab., 2020 August. Dostupné z: https://clinlabint.com/the-role-of-monocytes-in-theprogression- of-sepsis/

15. Ziegler-Heitbrock, L., Ancuta, P., Crowe, S., Dalod, M., Grau, V., Hart, DN., et al. Nomenclature of monocytes and dendritic cells in blood. Blood, 2010, 116(16), e74-80.

16. Greco, M., Mazzei, A., Palumbo, C., Verri, T., Lobreglio, G. Flow Cytometric Analysis of Monocytes Polarization and Reprogramming From Inflammatory to Immunosuppressive Phase During Sepsis. EJIFCC, 2019, 30(4), s. 371-384.

17. Arenson, E. B. Jr., Epstein, M. B., Seeger, R. C. Volumetric and functional heterogeneity of human monocytes. J Clin. Invest., 1980, 65(3), s. 613-8.

18. Crouser, E. D., Parrillo, J. E., Seymour, C., Angus, D. C., Bicking, K., Tejidor, L., et al. Improved Early Detection of Sepsis in the ED With a Novel Monocyte Distribution Width Biomarker. Chest, 2017, 152(3), s. 518-526.

19. Agnello, L., Sasso, B. L., Giglio, R. V., Bivona, G., Gambino, C. M., Cortegiani, A., et al. Monocyte distribution width as a biomarker of sepsis in the intensive care unit: A pilot study. Ann. Clin. Biochem., 2021, 58(1), s. 70-73.

20. Beckman Coulter, Inc. Early Sepsis Indicator (ESId) Application Addendum, PN C21894AC, April 2020.

21. Crouser, E. D., Parrillo, J. E., Seymour, C. W., Angus, D. C., Bicking, K., Esguerra, V. G., et. al. Monocyte Distribution Width: A Novel Indicator of Sepsis-2 and Sepsis-3 in High-Risk Emergency Department Patients. Crit Care Med., 2019, 47(8), s. 1018-1025.

22. Polilli, E., Sozio, F., Frattari, A., Persichitti, L., Sensi, M., Posata, R., et.al. Comparison of Monocyte Distribution Width (MDW) and Procalcitonin for early recognition of sepsis. PLoS One, 2020, 15(1), s. 1-13.

23. Crouser, E. D., Parrillo, J. E., Martin, G. S., Huang, D. T., Hausfater, P., Grigorov, I., et. al. Monocyte distribution width enhances early sepsis detection in the emergency department beyond SIRS and qSOFA. J Intens. Care, 2020, 8, s. 33-43.

24. Agnello, L., Bivona, G., Vidali, M., Scazzone, C., Giglio, R. V., Iacolino, G., et. al. Monocyte distribution width (MDW) as a screening tool for sepsis in the Emergency Department. Clin. Chem. Lab. Med., 2020, 58(11), s. 1951-1957.

25. Agnello, L., Lo Sasso, B., Bivona, G., Gambino, C. M., Giglio, R. V., Iacolino, G., et. al. Reference interval of monocyte distribution width (MDW) in healthy blood donors. Clin. Chim. Acta, 2020, 510, s. 272-277.

26. Agnello, L., Lo Sasso, B., Vidali, M., Scazzone, C., Gambino, C. M., Giglio, R. V., et. al. Validation of monocyte distribution width decisional cut-off for sepsis detection in the acute setting. Int. J Lab. Hematol., 2021, 43(4), O183-O185.

27. Piva, E., Zuin, J., Pelloso, M., Tosato, F., Fogar, P., Plebani, M. Monocyte distribution width (MDW) parameter as a sepsis indicator in intensive care units. Clin. Chem. Lab. Med., 2021, 59(7), s. 1307-1314.

28. Agnello, L., Iacona, A., Lo Sasso, B., Scazzone, C., Pantuso, M., Giglio, R. V., et. al. A new tool for sepsis screening in the Emergency Department. Clin. Chem. Lab. Med., 2021, 59(9), s. 1600-1605.

29. Woo, A., Oh, D. K., Park, C. J., Hong, S. B. Monocyte distribution width compared with C-reactive protein and procalcitonin for early sepsis detection in the emergency department. PLoS One, 2021, 16(4), e0250101.

30. Riva, G., Castellano, S., Nasillo, V., Ottomano, A. M., Bergonzini, G., Paolini, A., et. al. Monocyte Distribution Width (MDW) as novel inflammatory marker with prognostic significance in COVID-19 patients. Sci Rep., 2021, 11(1), 12716-12725.

31. Hausfater, P., Robert Boter, N., Morales Indiano, C., Cancella de Abreu, M., Marin, A. M., Pernet, J., et. al. Monocyte distribution width (MDW) performance as an early sepsis indicator in the emergency department: comparison with CRP and procalcitonin in a multicenter international European prospective study. Crit. Care., 2021, 25(1), 227-239.

32. Agnello, L., Iacona, A., Maestri, S., Lo Sasso, B., Giglio, R. V., Mancuso, S., et. al. Independent Validation of Sepsis Index for Sepsis Screening in the Emergency Department. Diagnostics (Basel), 2021, 11(7), s. 1292-1299.

33. Hou, S. K., Lin, H. A., Chen, S. C., Lin, C. F., Lin, S. F. Monocyte Distribution Width, Neutrophil-to-Lymphocyte Ratio, and Platelet-to-Lymphocyte Ratio Improves Early Prediction for Sepsis at the Emergency. J Pers. Med., 2021, 11(8), s. 732-746.

34. Ognibene, A., Lorubbio, M., Magliocca, P., Tripodo, E., Vaggelli, G., Iannelli, G., et. al. Elevated monocyte distribution width in COVID-19 patients: The contribution of the novel sepsis indicator. Clin. Chim. Acta, 2020, 509, s. 22-24.

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