Mucormycosis in solid organ transplant recipients
Authors:
S. Palásková; E. Kieslichová
Authors‘ workplace:
Klinika anesteziologie, resuscitace a intenzivní péče, Transplantcentrum, Institut klinické a experimentální medicíny
Published in:
Anest. intenziv. Med., 30, 2019, č. 2, s. 86-89
Category:
Intesive Care Medicine - Case Report
Overview
Mucormycosis is a very serious, invasive fungal infection, occurring frequently in patients with a modified immune response. Mortality in cases of a generalized form of mucormycosis can reach 96 %. The principles of successful treatment of this disease are early diagnosis and aggressive antimycotic and/or surgical therapy. In this case report we point out the clinical importance of correct timing of therapy, even though even early and appropriate management does not always guarantee survival.
Keywords:
solid organ transplantation – antimycotic therapy
Sources
1. Gavalda J, Meije Y, Fortún J, et al. Invasive fungal infections in solid organ transplant recipients. Clin Microbiol Infect. 2014;20:27–48.
2. Petrikkos G, Skiada A, Lortholary O, et al. Epidemiology and clinical manifestations of mucormycosis. Clin Infect Dis. 2012;54:23–34.
3. Neofytos D, Fishman JA, Horn D, et al. Epidemiology and outcome of invasive fungal infections in solid organ transplant recipients. Transpl Infect Dis. 2010;12:220–229.
4. Prabhu RM, Patel R. Mucormycosis and entomophthoramycosis: a review of the clinical manifestations, diagnosis and treatment. Clin Microbiol Infect. 2004;10:31–47.
5. Lemonovich TL. Mold infections in solid organ transplant recipients. Infect Dis Clin North Am. 2018;32:687–701.
6. Skiada A, Lass-Floerl C, Klimko N, et al. Challenges in the diagnosis and treatment of mucormycosis. Med Mycol. 2018;56:93–101.
7. Hammond PS, Bialek R, Milner DA, et al. Molecular methods to improve diagnosis and identification of mucormycosis. J Clin Microbiol. 2011;49:2151–2153.
8. Bialek R, Zelck UE. PCR-diagnostik von mukormykosen aus gewebeschnitten. Der Pathologe. 2013;34:511–518.
9. Liu M, Bruni GO, Taylor CM, et al. Comparative genome-wide analysis of extracellular small RNAs from the mucormycosis pathogen Rhizopus delemar. Sci Rep. 2018;8:5243.
10. Machouart M, Larché J, Burton K, et al. Genetic identification of the main opportunistic mucorales by PCR-restriction fragment length polymorphism. J Clin Microbiol. 2006;44:805–810.
Labels
Anaesthesiology, Resuscitation and Inten Intensive Care MedicineArticle was published in
Anaesthesiology and Intensive Care Medicine
2019 Issue 2
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