Soft tissue tumors - the view of the molecular biologist

Česká verze

Authors: Lenka Krsková; Marcela Mrhalová; Markéta Kalinová; Vít Campr; Linda Čapková; Marek Grega; Jaromír Háček; Ludmila Hornofová; Mária Chadimová; Renata Chmelová; Daniela Kodetová; Josef Zámečník; Roman Kodet
Authors place of work: Ústav patologie a molekulární medicíny, 2. LF UK a FN Motol
Published in the journal: Čes.-slov. Patol., 50, 2014, No. 3, p. 132-140
Category: Přehledový článek

Summary

Soft tissue tumors (SSTs) constitute a broad spectrum of neoplasms with diverse biological properties. Rare or unusual types are often difficult to classify. Recent studies show, that a significant subset of SSTs including many types of sarcomas are associated with specific genetic changes such as chromosomal translocations producing chimeric genes, which play a role in the pathogenesis of SSTs. Because SSTs represent a diagnostically challenging group of tumors, molecular-genetic techniques (FISH or PCR) are useful as supplementary and/or confirmatory diagnostic tools. In the present paper we demonstrate the usefulness of a combined diagnostic approach using the tools of classical histopathology and immunohistochemistry together with the molecular diagnostic approach in selected nosologic entites.

Keywords:
soft tissue tumors – translocation – RT-PCR

Zdroje

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