Mucinózny adenokarcinóm (neintestinálneho typu) vzniknutý v zrelom cystickom teratóme vaječníka - kazuistika

English version

Autoři: Karol Kajo ¹; Ladislav Masák ²; Dagmar Sorkovská ³; Miroslava Vallová ¹; Michal Kajo ¹; Katarína Macháleková ¹; Lýdia Heľpianská ⁴
Působiště autorů: Department of Pathology, St. Elisabeth Cancer Institute, Bratislava, Slovakia ¹; Department of Gynaecological Oncology, St. Elisabeth Cancer Institute, Bratislava, Slovakia ²; Department of Clinical Oncology, St. Elisabeth Cancer Institute, Bratislava, Slovakia ³; 1st Department of Oncology, St. Elisabeth Cancer Institute, Bratislava, Slovakia ⁴
Vyšlo v časopise: Čes.-slov. Patol., 49, 2013, No. 4, p. 141-145
Kategorie: Původní práce

Souhrn

Malígna somatická transformácia v zrelom cystickom teratóme je zriedkavý fenomén, pri ktorom vzniká zhubný nádor z diferencovaných tkanivových štruktúr niektorého zo zárodočných listov.

Autori prezentujú prípad 38 - ročnej ženy so zrelým cystickým teratómom oboch vaječníkov a mucinóznym adenokarcinómom vzniknutým z endodermálnej zárodočnej línie v pravom ováriu, ktorý imunohistochemicky vykazoval charakteristiky non-intestinálnej diferenciácie. V čase diagnostiky nádor metastázoval do panvových a retroperitoneálnych lymfatických uzlín.

Pacientka bola liečená troma líniami chemoterapie a po 15 mesiacoch od stanovenia diagnózy zomrela za príznakov progresie vo forme masívnej nádorovej propagácie do retroperitoneálnych, mediastinálnych a krčných lymfatických uzlín, infiltrácie retroperitonea a duodena a peritoneálneho rozsevu.

Malígna somatická transformácia v zrelom cystickom teratóme je spojená so zlou prognózou. Najdôležitejším prognostickým faktorom je štádium v čase stanovenia diagnózy.

Kľúčové slová:
ovárium – zrelý cystický teratóm – malígna transformácia – adenokarcinóm – nádorový marker

Zdroje

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