Atypical picture of colon infiltration with lymphoma in a patient with chronic lymphocytic leukaemia

Česká verze

Authors: J. Štefánek ¹; Petra Morávková ² ; P. Žák ³; J. Laco ⁴; M. Nová ⁴; M. Kopáčová ²
Authors place of work: Interní oddělení, Nemocnice Havlíčkův Brod ¹; II. interní gastroenterologická klinika LF UK a FN Hradec Králové ²; IV. interní hematologická klinika LF UK a FN Hradec Králové ³; Fingerlandův ústav patologie, LF UK a FN Hradec Králové ⁴
Published in the journal: Gastroent Hepatol 2015; 69(2): 141-145
Category: Gastrointestinální onkologie: kazuistika
doi: https://doi.org/10.14735/amgh2015141

Summary

We present a case of a 63‑year‑ old patient with chronic lymphocytic leukaemia and vague dyspeptic symptoms. The endoscopic image of the large intestine and terminal ileum detected multiple nodular and polypous lesions. Histological examination of biopsy specimens confirmed significant affection of both small and large intestinal mucosa by B‑ cell small lymphocytic lymphoma.

Key words:
chronic – lymphocytic – leukaemia – colonoscopy – intestines – lymphoma

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Submitted:
9. 2. 2015

Accepted:
7. 4. 2015

Zdroje

1. Fenoglio‑ Preiser CM, Noffsinger AE, Stemmermann GN et al. Gastrointestinal pathology: an atlas and text. 3. ed. Philadelphia: Lippincott Williams & Wilkins 2008: 1179– 1185.

2. Kumar V, Abbas AK, Fausto N et al. Robbins basic pathology. 8. ed. London: W. B. Saunders 2007; 450– 451, 626– 627.

3. Brejcha M, Mayer J, Doubek M et al. Chronická lymfatická leukémie: diagnostika a léčba. Nový Jičín: Onkologické centrum J. G. Mendela, Centrum pro prombózu a hemostázu 2005. [online]. Dostupné z: http:/ / www.onkologickecentrum.cz/ downloads/ prirucky/ guidelines‑ cll‑ ocjgm‑ vi06.pdf.

4. Smolej L. Současné možnosti léčby chronické lymfocytární leukemie. [online]. Dostupné z: http:/ / www.remedia.cz/ Okruhy‑ temat/ Hematologie/ Soucasne‑ moznosti‑ lecby‑ chronicke‑lymfocytarni‑ leukemie/ 8- 15- Qa.magarticle.aspx.

5. Tabata R, Tabata C, Nagai T et al. Richter syndrome with follicular colonization of chronic lymphocytic leukemia/ small lymphocytic lymphoma cells mimicking follicular lymphoma. Int J Surg Pathol 2014; 22(8); 736– 743. doi: 10.1177/ 1066896913509011.

6. Kuse R, Lueb H. Gastrointestinal involvement in patients with chronic lymphocytic leukemia. Leukemia 1997; 11 (Suppl 2): S50– S51.

7. Abella E, Gimenez T, Gimeno J et al. Diarrheic syndrome as a clinical sign of intestinal infiltration in progressive B‑ cell chronic lymphocytic leukemia. Leuk Res 2009; 33(1): 159– 161. doi: 10.1016/ j.leukres.2008.03.023.

8. Malhotra P, Singh M, Kochhar R et al. Leukemia infiltration of bowel in chronic lymphocytic leukemia. Gastrointest Endosc 2005; 62(4): 614– 615.

9. Lalani M, Rhee JC, Gutkin DW et al. Uncommon presentations of some common malignancies: case 3. Chronic lymphocytic leukemia involving the colon and presenting with perforation. J Clin Oncol 2005; 23(6): 1315– 1317.

10. Smith GM, Chesner IM, Asquith P et al. Small intestinal bacterial overgrowth in patients with chronic lymphocytic leukaemia. J Clin Pathol 1990; 43(1): 57– 59.

11. Krishna SG, Reddy SR, Sargent RL et al. Colonic lymphocytic infiltration in chronic lymphocytic leukemia. [online]. Available from: http:/ / www.vhjoe.org/ index.php/ vhjoe/ article/ view/ 68/ 106.

12. Gonçalves R, Sousa R, Banhudo A et al. Endoscopic findings in chronic lymphocytic leukemia. Am J Clin Oncol 2000; 23(6): 599– 601.

13. Khaled S, Gotlieb V, Schuster IP et al. Multiple lymphomatous polyposis associated with small lymphocytic lymphoma: a unique presentation. J Gastrointestin Liver Dis 2008; 17(4): 461– 463.

14. Romaguera J, Hagemeister FB. Lymphoma of the colon. Curr Opin Gastroenterol 2005; 21(1): 80– 84.

15. Arkkila PE, Nuutinen H et al. Colonic involvement in a patient with chronic lymphocytic leukaemia. Gastroenterol Res Pract 2008; 2008: 742146. doi: 10.1155/ 2008/ 742146.