Jsou některé vakcíny COVID-19 lepší než jiné, pokud jde o krátkodobé nežádoucí účinky?

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Autoři: Radhwan Al-Zidan; Omeed Darweesh; Muhanad Salah; Pshtiwan Bebane; Hemn Ahmed; Ghayth Abdulrazzaq; Sadeel Shanshal; Nohad Alomari
Vyšlo v časopise: Čes. slov. Farm., 2023; 72, 45-54
Kategorie: Původní práce
doi: https://doi.org/https://doi.org/10.5817/CSF2023-1-45

Souhrn

Zvládnutí pandemie se dosahuje především očkováním proti COVID-19. Ačkoliv se ve světě používají různé vakcíny proti COVID-19, o jejich bezpečnosti a vedlejších účincích je známo jen málo. Cílem tohoto výzkumu je proto zjistit krátkodobé vedlejší účinky různých vakcín proti COVID-19 používaných v Iráku. Dále bylo cílem prozkoumat souvislost mezi pociťovanými nežádoucími účinky a značkou podané vakcíny. Současná studie hodnotila krátkodobé vedlejší účinky vakcín Pfizer, Sinopharm a AstraZeneca u pracovníků ve zdravotnictví v Iráku. Ve studii byl použit dotazník, který se skládal ze speciálních částí pro sběr demografických údajů, značky obdržené vakcíny covid-19, krátkodobých nežádoucích účinků a ochoty obdržet třetí posilovací dávku. Pokud jde o vedlejší účinky po očkování, studované vakcíny COVID-19 vykazovaly srovnatelnou škálu vedlejších účinků, jako jsou bolesti hlavy, horečka, bolesti svalů, bolesti kloubů, malátnost, citlivost, zarudnutí a také bolest v místě očkování. Vakcína Pfizer však vykazovala vyšší výskyt bolesti a citlivosti v místě vpichu a horečky ve srovnání s vakcínami AstraZeneca a Sinopharm. Na druhou stranu vakcína Sinopharm byla ve srovnání s vakcínami Pfizer a AstraZeneca spojena s vyšším výskytem bolestí hlavy, svalů, kloubů a malátnosti. Souhrnně lze říci, že krátkodobé nežádoucí účinky všech tří vakcín byly srovnatelné, nicméně vakcína AstraZeneca byla spojena s nižším rizikem výskytu nežádoucích účinků.

Klíčová slova:

nežádoucí účinky – COVID-19 – vakcína – Pfizer – Sinopharm – AstraZeneca – Sputnik V

Zdroje

1. Alagoz O., Sethi A. K., Patterson B. W., Churpek M., Alhanaee G., Scaria E., Safdar N. The impact of vaccination to control COVID-19 burden in the United States: A simulation modeling approach. PLoS One 2021; 16, e0254456. https://doi.org/10.1371/journal.pone.0254456

2. Alhazmi A., Alamer E., Daws D., Hakami M., Darraj M., Abdelwahab S., Maghfuri A., Algaissi A. Evaluation of Side Effects Associated with COVID-19 Vaccines in Saudi Arabia. Vaccines 2021; 9, 674. https://doi.org/10.3390/ vaccines9060674

3. Alkotaji M., Al-Zidan R. N. Indomethacin: Can It Counteract Bradykinin Effects in COVID-19 Patients? Curr. Pharmacol. Rep. 2021; 7, 102–106. https://doi.org/10.1007/ s40495-021-00257-6

4. Almufty H. B., Mohammed S. A., Abdullah A. M., Merza M. A. Potential adverse effects of COVID19 vaccines among Iraqi population; a comparison between the three available vaccines in Iraq; a retrospective cross-sectional study. Diabetes Metab. Syndr. 2021; 15, 102207. https://doi.org/10.1016/j.dsx.2021.102207

5. Al-Qazaz H. K., Al-Obaidy L. M., Attash H. M. COVID-19 vaccination, do women suffer from more side effects than men? A retrospective cross-sectional study. Pharm. Pract. 2022; 20, 2678–2678. https://doi.org/10.18549/ PharmPract.2022.2.2678

6. Alsaaty M. H., Alyouzbaki A. Z., Younis W. T. The impact of smoking on severity and outcome in patients with covid-19 infection in Mosul city. Mil. Med. Sci. Lett. 2022; 91, 98–104. https://doi.org/10.31482/mmsl.2021.044

7. Althanoon Z. A. Evaluation of the therapeutic effects of combined hydroxychloroquine and azithromycine in patients with covid-19. MMSL 2022; 91, 216–223. https:// doi.org/10.31482/mmsl.2021.045

8. Alzarea A. I., Khan Y. H., Alatawi A. D., Alanazi A. S., Alzarea S. I., Butt M. H., Almalki Z. S., Alahmari A. K., Mallhi T. H. Surveillance of Post-Vaccination Side Effects of COVID-19 Vaccines among Saudi Population: A Real- World Estimation of Safety Profile. Vaccines 2022; 10, 924. https://doi.org/10.3390/vaccines10060924

9. Al-Zidan R. N. Potential Drug-Drug and Drug-Disease interactions of selected experimental therapies used in treating COVID-19 patients. J. Drug Deliv. Ther. 2020; 10, 219–230. https://doi.org/10.22270/jddt.v10i6.4383

10. Attia S., Howaldt H.-P. Impact of COVID-19 on the Dental Community: Part I before Vaccine (BV). J. Clin. Med. 2021; 10, 288. https://doi.org/10.3390/jcm10020288

11. Baden L. R., El Sahly H. M., Essink B., Kotloff K., Frey S., Novak R., Diemert D., Spector S. A., Rouphael N., Creech C. B., McGettigan J., Khetan S., Segall N., Solis J., Brosz A., Fierro C., Schwartz H., Neuzil K., Corey L., Gilbert P., Janes H., Follmann D., Marovich M., Mascola J., Polakowski L., Ledgerwood J., Graham B. S., Bennett H., Pajon R., Knightly C., Leav B., Deng W., Zhou H., Han S., Ivarsson M., Miller J., Zaks T. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. N. Engl. J. Med. 2021; 384, 403–416. https://doi.org/10.1056/NEJMoa2035389

12. Callaway E. The race for coronavirus vaccines: a graphical guide. Nature 2020; 580, 576–577. https://doi. org/10.1038/d41586-020-01221-y

13. Cuschieri S., Borg M., Agius S., Souness J., Brincat A., Grech V. Adverse reactions to Pfizer-BioNTech vaccination of healthcare workers at Malta’s state hospital. Int. J. Clin. Pract. 2021; 75, e14605. https://doi.org/10.1111/ ijcp.14605

14. Darweesh O., Abdulrazzaq G. M., Al-Zidan R. N., Bebane P., Merkhan M., Aldabbagh R., AlOmari N. Evaluation of the Pharmacologic Treatment of COVID-19 Pandemic in Iraq. Curr. Pharmacol. Rep. 2021; 7, 171–178. https://doi.org/10.1007/s40495-021-00262-9

15. Elgendy M. O., Abdelrahim M. E. A. Public awareness about coronavirus vaccine, vaccine acceptance, and hesitancy. J. Med. Virol. 2021; 93, 6535–6543. https://doi. org/10.1002/jmv.27199

16. Elgendy M. O., El-Gendy A. O., Alzarea A. I., Mahmoud S., Alqahtani S. S., Fahmy A. M., El-Seedi H. R., Sayed A. M., Alatawi A. D., Abdelrahim M. E. A., Alanazi A. S. SARS-CoV-2 Post Vaccinated Adverse Effects and Efficacy in the Egyptian Population. Vaccines 2022; 10, 18. https://doi.org/10.3390/vaccines10010018

17. El-Shitany N. A., Harakeh S., Badr-Eldin S. M., Bagher A. M., Eid B., Almukadi H., Alghamdi B. S., Alahmadi A. A., Hassan N. A., Sindi N., Alghamdi S. A., Almohaimeed H. M., Mohammedsaleh Z. M., Al-Shaikh T. M., Almuhayawi M. S., Ali S. S., El-Hamamsy M. Minor to Moderate Side Effects of Pfizer-BioNTech COVID-19 Vaccine Among Saudi Residents: A Retrospective Cross-Sectional Study. Int. J. Gen. Med. 2021; 14, 1389–1401. https://doi.org/10.2147/IJGM.S310497

18. El-Sokkary R. H., El Seifi O. S., Hassan H. M., Mortada E. M., Hashem M. K., Gadelrab M. R. M. A., Tash R. M. E. Predictors of COVID-19 vaccine hesitancy among Egyptian healthcare workers: a cross-sectional study. BMC Infect. Dis. 2021; 21, 762. https://doi.org/10.1186/ s12879-021-06392-1

19. Galindo R., Chow H., Rongkavilit C. COVID-19 in Children: Clinical Manifestations and Pharmacologic Interventions Including Vaccine Trials. Pediatr. Clin. North Am. 2021; 68, 961–976. https://doi.org/10.1016/j. pcl.2021.05.004

20. Ganesan S., Al Ketbi L. M .B., Al Kaabi N., Al Mansoori M., Al Maskari N. N., Al Shamsi M. S., Alderei A. S., El Eissaee H. N., Al Ketbi R. M., Al Shamsi N. S., Saleh K. M., Al Blooshi A. F., Cantarutti F. M., Warren K., Ahamed F., Zaher W. Vaccine Side Effects Following COVID-19 Vaccination Among the Residents of the UAE – An Observational Study. Front. Public Health 2022; 10, 876336. https://doi.org/10.3389/fpubh.2022.876336

21. Gorial F. I., Abdulrahman Younis A., Alkazzaz A., Arif Maroof A. M., Qaradaghi T. A., Mahmood C. H., ALosami M. H., Yasiry D. S., Ihsan Awadh N., Younis M. M., Mahdi F. J., Mihan S. W., Jassim N. A. Covid-19 among a sample of iraqi patients with rheumatic diseases: a multicenter study. MMSL 2022; 91, 89–97. https://doi. org/10.31482/mmsl.2021.038

22. Hatmal M. M., Al-Hatamleh M. A. I., Olaimat A. N., Hatmal M., Alhaj-Qasem D. M., Olaimat T. M., Mohamud R. Side Effects and Perceptions Following COVID-19 Vaccination in Jordan: A Randomized, Cross-Sectional Study Implementing Machine Learning for Predicting Severity of Side Effects. Vaccines 2021; 9, 556. https://doi. org/10.3390/vaccines9060556

23. Hause A. M. Safety Monitoring of an Additional Dose of COVID-19 Vaccine — United States, August 12–September 19, 2021. MMWR Morb. Mortal. Wkly. Rep. 2021; 70. https://doi.org/10.15585/mmwr.mm7039e4

24. Almufty HB, Mohammed SA, Abdullah AM, Merza MA. Potential adverse effects of COVID19 vaccines among Iraqi population; a comparison between the three available vaccines in Iraq; a retrospective cross-sectional study. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2021; 15(5), 102207.

25. Hervé C., Laupèze B., Del Giudice G., Didierlaurent A .M., Tavares Da Silva F. The how’s and what’s of vaccine reactogenicity. Npj Vaccines 2019; 4, 1–11. https:// doi.org/10.1038/s41541-019-0132-6

26. Im J. H., Kim E., Lee E., Seo Y., Lee Y., Jang Y., Yu S., Maeng Y., Park Soyeon, Park Seohee, Kim J., Lee J.- S., Baek J. H. Adverse Events with the Pfizer-BioNTech COVID-19 Vaccine among Korean Healthcare Workers. Yonsei Med. J. 2021; 62, 1162–1168. https://doi. org/10.3349/ymj.2021.62.12.1162

27. Inactivated Influenza Vaccine Information Statement | CDC [www Document], 2022. URL https://www.cdc.gov/ vaccines/hcp/vis/vis-statements/flu.html (12.23.22).

28. Jackson L. A., Anderson E. J., Rouphael N. G., Roberts P. C., Makhene M., Coler R. N., McCullough M. P., Chappell J. D., Denison M. R., Stevens L. J., Pruijssers A. J., McDermott A., Flach B., Doria-Rose N. A., Corbett K. S., Morabito K. M., O’Dell S., Schmidt S. D., Swanson P. A., Padilla M., Mascola J. R., Neuzil K. M., Bennett H., Sun W., Peters E., Makowski M., Albert J., Cross K., Buchanan W., Pikaart-Tautges R., Ledgerwood J. E., Graham B. S., Beigel J. H. An mRNA Vaccine against SARSCoV- 2 — Preliminary Report. N. Engl. J. Med. 2020; 383, 1920–1931. https://doi.org/10.1056/NEJMoa2022483

29. Jarrett C., Wilson R., O’Leary M., Eckersberger E., Larson H. J., SAGE Working Group on Vaccine Hesitancy. Strategies for addressing vaccine hesitancy – A systematic review. Vaccine 2015; 33, 4180–4190. https://doi. org/10.1016/j.vaccine.2015.04.040

30. Kadali R. A. K., Janagama R., Peruru S., Malayala S. V. Side effects of BNT162b2 mRNA COVID-19 vaccine: A randomized, cross-sectional study with detailed self-reported symptoms from healthcare workers. Int. J. Infect. Dis. 2021; 106, 376–381. https://doi.org/10.1016/j.ijid.2021.04.047

31. Li P., Fu J.-B., Li K.-F., Liu J.-N., Wang H.-L., Liu L.-J., Chen Y., Zhang Y.-L., Liu S.-L., Tang A., Tong Z.-D., Yan J.-B. Transmission of COVID-19 in the terminal stages of the incubation period: A familial cluster. Int. J. Infect. Dis. 2020; 96, 452–453. https://doi.org/10.1016/j. ijid.2020.03.027

32. Marzo R. R., Sami W., Alam Md. Z., Acharya S., Jermsittiparsert K., Songwathana K., Pham N. T., Respati T., Faller E. M., Baldonad, A. M., Aung Y., Borkar S. M., Essar M. Y., Shrestha S., Yi S. Hesitancy in COVID-19 vaccine uptake and its associated factors among the general adult population: a cross-sectional study in six Southeast Asian countries. Trop. Med. Health 2022; 50, 4. https:// doi.org/10.1186/s41182-021-00393-1

33. Menn C., Klaser K., May A., Polidori L., Capdevila J., Louca P., Sudre C. H., Nguyen L. H., Drew D. A., Merino J., Hu C., Selvachandran S., Antonelli M., Murray B., Canas L. S., Molteni E., Graham M. S., Modat M., Joshi A. D., Mangino M., Hammers A., Goodman A. L., Chan A. T., Wolf J., Steves C. J., Valdes A. M., Ourselin S., Spector T. D. Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study. Lancet Infect. Dis. 2021; 21, 939–949. https://doi. org/10.1016/S1473-3099(21)00224-3

34. Mohammed R. A., Garout R. M., Wahid S., Ayub F., Firas ZinAlddin L. M., Sultan I. A Survey on the Side Effects of Pfizer/BioNTech COVID-19 Vaccine Among Vaccinated Adults in Saudi Arabia. Cureus 2021; 13, e19222. https://doi.org/10.7759/cureus.19222

35. Possible Side effects from Vaccines | CDC [www Document], 2022. URL https://www.cdc.gov/vaccines/vacgen/ side-effects.htm (12.23.22).

36. Riad A., Hocková B., Kantorová L., Slávik R., Spurná L., Stebel A., Havriľak M., Klugar M. Side Effects of mRNA-Based COVID-19 Vaccine: Nationwide Phase IV Study among Healthcare Workers in Slovakia. Pharm. Basel Switz. 2021a; 14, 873. https://doi.org/10.3390/ ph14090873

37. Riad A., Pokorná A., Attia S., Klugarová J., Koščík M., Klugar M. Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic. J. Clin. Med. 2021b; 10, 1428. https://doi.org/10.3390/ jcm10071428

38. Smith L. E., Amlôt R., Weinman J., Yiend J., Rubin G. J. A systematic review of factors affecting vaccine uptake in young children. Vaccine 2017; 35, 6059–6069. https:// doi.org/10.1016/j.vaccine.2017.09.046

39. Solomon Y., Eshete T., Mekasha B., Assefa W. COVID-19 Vaccine: Side Effects After the First Dose of the Oxford AstraZeneca Vaccine Among Health Professionals in Low-Income Country: Ethiopia. J. Multidiscip. Healthc. 2021; 14, 2577–2585. https://doi.org/10.2147/JMDH. S331140

40. Tahir A. I., Ramadhan D. S., Piro S. S., Abdullah R. Y., Taha A. A., Radha R. H. COVID-19 vaccine acceptance, hesitancy and refusal among Iraqi Kurdish population. Int. J. Health Sci. 2022; 16, 10–16.

41. Teh H. S., Woon Y. L., Leong C. T., Hing N. Y. L., Mien T. Y. S., Roope L. S. J., Clarke P. M., Lim L.-L., Buckell J. Malaysian public preferences and decision making for COVID-19 vaccination: A discrete choice experiment. Lancet Reg. Health – West. Pac. 2022; 27. https://doi. org/10.1016/j.lanwpc.2022.100534

42. Zhai P., Ding Y., Wu X., Long J., Zhong Y., Li, Y. The epidemiology, diagnosis and treatment of COVID-19. Int. J. Antimicrob. Agents 2020; 55, 105955. https://doi. org/10.1016/j.ijantimicag.2020.105955

43. Zhan Y., Zeng G., Pan H., Li C., Hu Yaling, Chu K., Han W., Chen Z., Tang R., Yin W., Chen X., Hu Yuansheng, Liu X., Jiang C., Li J., Yang M., Song Y., Wang X., Gao Q., Zhu F. Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18–59 years: a randomised, double-blind, placebo- controlled, phase 1/2 clinical trial. Lancet Infect. Dis. 2021; 21, 181–192. https://doi.org/10.1016/S1473- 3099(20)30843-4

44. Zhou G., Chen S., Chen Z. Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies. Front. Med. 2020; 14, 117–125. https://doi.org/10.1007/s11684-020-0773-x