A primary cutaneous carcinosarcoma of the retro auricular region, how to treat and literature review

1. Kwak HB., Park J., Kim HU., et al. Cutaneous carcinosarcoma: a clinicopathologic and immunohistochemical analysis of 11 Korean cases. J Korean Med Sci. 2019, 34 (1): e5.

2. Ram R., Saadat P., Peng D., et al. Primary cutaneous carcinosarcoma. Ann Clin Lab Sci. 2005, 35 (2): 189–194.

3. Müller CS., Pföhler C., Schiekofer C., et al. Primary cutaneous carcinosarcomas: a morphological histogenetic concept revisited. Am J Dermatopathol. 2014, 36 (4): 328–339.

4. Gungorduk K., Ozdemir A., Ertas IE., et al. Adjuvant treatment modalities, prognostic predictors and outcomes of uterine carcinosarcomas. Cancer Res Treat. 2015, 47 (2): 282–289.

5. García-Souto F., Pereyra-Rodriguez JJ., Cabrera-Perez R., et al. Primary cutaneous carcinosarcoma: clinical, histological, and immunohistochemical analysis of eight cases. Int J Dermatol. 2021, 60 (1): 93–98.

6. Tran TA., Muller S., Chaudahri PJ., et al. Cutaneous carcinosarcoma: adnexal vs. epidermal types define highand low-risk tumors. Results of a meta-analysis. J Cutan Pathol. 2005, 32 (1): 2–11.

7. Bigby SM., Charlton A., Miller MV., et al. Biphasic sarcomatoid basal cell carcinoma (carcinosarcoma): four cases with immunohistochemistry and review of the literature. J Cutan Pathol. 2005, 32 (2): 141–147.

8. Dawson EK. Carcino-sarcoma of the skin. J R Coll Surg Edinb. 1972, 17 (4): 243–246.

9. Syme-Grant J., Syme-Grant NJ., Motta L., et al. Are primary cutaneous carcinisarcomas underdiagnosed? Five cases and a review of the literature. J Plast Reconstr Aesthet Surg. 2006, 59 (12): 1402–1408.

10. Gómez-Espejo C., Herrera-Sabal A., Ríos-Martín JJ., et al. Basal cell carcinoma with sarcomatoid features (sarcomatoid carcinoma): report of a case and review of the literature. J Dermatol. 2003, 30 (7): 543–549.

11. Ndukwe CO., Chiemeka ME., Menkiti FE., et al. Primary carcinosarcoma of the skin in an African albino: case report and review of literature. Oman Med J. 2022, 37 (5): e417.

12. Liaw TY. Primary cutaneous sarcomatoid carcinoma presenting as a rapidly-growing and ulcerative tumor of the skin. Kaohsiung J Med Sci. 2017, 33 (6): 315–317.

13. Moore DJ., Powis G., Richardson RL., et al. Topical chemotherapy of intradermal Walker 256 carcinosarcoma with diaziquone and doxorubicin in the rat. Cancer Res. 1985, 45 (11 Pt 1): 5466–5472.

14. Patel NK., McKee PH., Smith NP., et al. Primary metaplastic carcinoma (carcinosarcoma) of the skin. A clinicopathologic study of four cases and review of the literature. Am J Dermatopathol. 1997, 19 (4): 363–372.

15. Luong TMH., Akazawa Y., Mussazhanova Z., et al. Cutaneous pilomatrical carcinosarcoma: a case report with molecular analysis and literature review. Diagn Pathol. 2020, 15 (1): 7.

16. Rose RF., Merchant W., Stables GI., et al. Basal cell carcinoma with a sarcomatous component (carcinosarcoma): a series of 5 cases and a review of the literature. J Am Acad Dermatol. 2008, 59 (4): 627–632.

17. Loh TL., Tomlinson J., Chin R., et al. Cutaneous carcinosarcoma with metastasis to the parotid gland. Case Rep Otolaryngol. 2014, 2014: 173235.

18. Zbacnik AP., Rawal A., Lee B., et al. Cutaneous basal cell carcinosarcoma: case report and literature review. J Cutan Pathol. 2015, 42 (11): 903–910.

19. Clark JJ., Bowen AR., Bowen GM., et al. Cutaneous carcinosarcoma: a series of six cases and a review of the literature. J Cutan Pathol. 2017, 44 (1): 34–44.

20. Wollina U., Riedel I., Abushika MR., et al. Giant pendulous carcinosarcoma – squamous cell carcinoma-type – of the leg – a case report and review of the literature. Open Access Maced J Med Sci. 2018, 6 (1): 112–114.

21. Davis K., Whale K., Tran S., et al. A rare case of cutaneous basal cell carcinosarcoma in an immunosuppressed patient. Pathology. 2020, 52 (2): 267–268.

22. Song EY., Wallace SJ., Sheikh H., et al. Cutaneous carcinosarcoma: a small case series and review of the literature of a rare skin tumor. Cureus. 2020, 12 (8): 10.

23. Lim Y., Byun HJ., Park CS., et al. Primary cutaneous carcinosarcoma developing after chronic C-arm radiation exposure. JAAD Case Rep. 2018, 4 (2): 126–128.

24. Cervoni G., Steffes WE., Kobraei KB., et al. Exophytic scalp tumor the diagnosis: primary cutaneous carcinosarcoma. Cutis. 2016, 97 (4): E9–E11.

25. Ruiz-Villaverde R., Aneiros-Fernández J. Primary cutaneous carcinosarcoma: a cutaneous neoplasm with an exceptional presentation. Sultan Qaboos Univ Med J. 2018, 18 (1): e114–e115.

26. Kiuru M., McDermott G., Coit DC., et al. Basal cell carcinosarcoma with PTCH1 mutations in both epithelial and sarcomatoid primary tumor components and in the sarcomatoid metastasis. Am J Surg Pathol. 2014, 38 (1): 138–142.

27. Ansari-Lari MA., Hoque MO., Califano J., et al. Immunohistochemical p53 expression patterns in sarcomatoid carcinomas of the upper respiratory tract. Am J Surg Pathol. 2002, 26 (8): 1024–1031.

28. Tan KB., Murali R., Karim RZ., et al. Merkel cell carcinoma with fibrosarcomatous differentiation. Pathology. 2008, 40 (3): 314–316.

29. Agostini T., Mori A., Leporatti G., et al. Cutaneous carcinosarcoma: report of a case with myofibroblastic sarcomatous component. Dermatol Surg. 2008, 34 (3): 418–422.

30. Patterson JW. Tumors of the epidermis. In: Wheedon‘s Skin Pathology. Elsevier 2016: 784–835.

31. Blake PW., Bradford PT., Devesa SS., et al. Cutaneous appendageal carcinoma incidence and survival patterns in the United States: a population-based study. Arch Dermatol. 2010, 146 (6): 625–632.

32. Hong SH., Hong SJ., Lee Y., et al. Primary cutaneous carcinosarcoma of the shoulder: case report with literature review. Dermatol Surg. 2013, 39 (2): 338–340.

33. El Harroudi T., Ech-Charif S., Amrani M., et al. Primary carcinosarcoma of the skin. J Hand Microsurg. 2010, 2 (2): 79–81.

34. Kim C., Brown A., Osipov V. Trichoblastic carcinosarcoma in a 34-year-old woman with histopathologic and molecular analysis, including re-demonstration of a CDKN2A p. (R58*) mutation. J Cutan Pathol. 2021, 48 (2): 334–339.

35. Chittari K., Birnie AJ., Kulkarni KR., et al. Sarcomatoid carcinoma of the hand: a clinical case with an aggressive and uncommon presentation. Clin Exp Dermatol. 2012, 37 (5): 505–508.

36. Suzuki H., Hashimoto A., Saito R., et al. A case of primary cutaneous basal cell carcinosarcoma. Case Rep Dermatol. 2018, 10 (2): 208–215.

37. Etzkorn JR., Alam M. What is mohs surgery? JAMA Dermatology. 2020, 156 (6): 716.

38. Fania L., Didona D., Morese R., et al. Basal cell carcinoma: from pathophysiology to novel therapeutic approaches. Biomedicines. 2020, 8 (11): 449.

39. Bourgeault E., Alain J., Gagné E. Primary cutaneous carcinosarcoma of the basal cell subtype should be treated as a high-risk basal cell carcinoma. J Cutan Med Surg. 2015, 19 (4): 407–411.

40. Underwood CIM., Mansoori P., Selim AM., et al. Trichoblastic carcinosarcoma: a case report and literature review. J Cutan Pathol. 2020, 47 (4): 409–413.

41. Leen EJ., Saunders MP., Vollum DI., et al. Carcinosarcoma of skin. Histopathology. 1995, 26 (4): 367–371.

42. Xu C., Ibbetson J., Yeoh TM., et al. Aggressive growth of an incompletely excised primary cutaneous basal cell carcinosarcoma on the scalp: a case report. ANZ J Surg. 2016, 86 (12): 1065–1066.

43. Okhremchuk I., Nguyen AT., Fouet B., et al. Trichoblastic carcinosarcoma of the skin: a case report and literature review. Am J Dermatopathol. 2018, 40 (12): 917–919.

44. Bakhshi GD., Wankhede KR., Tayade MB., et al. Carcino-sarcoma in a case of syringocystadenoma papilliferum: a rare entity. Clin Pract. 2012, 2 (3): e71.

45. Ishikawa M., Nakanishi Y., Yamazaki N., et al. Malignant eccrine spiradenoma: a case report and review of the literature. Dermatol Surg. 2001, 27 (1): 67–70.

46. De Francesco V., Frattasio A., Pillon B., et al. Carcinosarcoma arising in a patient with multiple cylindromas. Am J Dermatopathol. 2005, 27 (1): 21–26.

47. Konstantinidis A., Ghosh Y., Snead D., et al. Eyelid basal cell carcinoma with osteosarcomatous changes. Ophthalmic Plast Reconstr Surg. 2008, 24 (4): 322–323.

48. Venishetty N., Shah KM., Nijhawan RI. Primary cutaneous carcinosarcoma treated with mohs micrographic surgery in a hospice patient. Dermatol Surg. 2022, 48 (12): 1359–1360.

49. Scholl P., Snyder N., Patt D., et al. Pilomatrical carcinosarcoma. Otolaryngol Head Neck Surg. 2010, 143 (5 Suppl 3): 36–37.

50. Wollina U., Koch A., Schönlebe J., et al. Carcinosarcoma of skin (sarcomatoid carcinoma) – a rare non-melanoma skin cancer (case review). Georgian Med News. 2017, (263): 7–10.

51. Sangjin O., Haneul L., Sungyul L., et al. Primary cutaneous sarcomatoid carcinoma. Indian J Dermatol Venereol Leprol. 2012, 78 (5): 665.

Coskun Arkaz, MD
Faculty of Medicine and Health Sciences Antwerp University
Universiteitsplein 1
2610 Wilrijk (Antwerp)
Belgium
e-mail: Coskunarkaz@gmail.com

Submitted: 28. 8. 2023
Accepted: 7. 2. 2024